Disorder "Arterial Stiffness Measurement"
Found 1 record
Disorder information
Disorder name:
Arterial Stiffness Measurement
Disoder ID:
Synonyms:
arterial stiffness
Definition:
Arterial stiffness occurs as a consequence of biological aging and arteriosclerosis. Inflammation plays a major role in arteriosclerosis development, and consequently it is a major contributor in large arteries stiffening. Increased arterial stiffness is associated with an increased risk of cardiovascular events such as myocardial infarction and stroke, the two leading causes of death in the developed world. The World Health Organization predicts that in 2010, cardiovascular disease will also be the leading killer in the developing world and represents a major global health problem.
Modifier statisitcs
Record:
1
Gene:
1
Variant:
1
Reference:
1
Effect type:
Expressivity(1)
Modifier effect:
Altered susceptibility(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| HFE | HFE:c.187C>G(p.His63Asp) | Expressivity | Altered susceptibility | P-interaction = 0.03 for tibia and 0.02 for patella | The HFE H63D polymorphism, appears to enhance susceptibility to the deleterious impact of cumulative lead on PP, possibly via prooxidative or pro-inflammatory mechanisms.more | more |
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