Disorder "Primary Progressive Multiple Sclerosis"
Found 1 record
Disorder information
Disorder name:
Primary Progressive Multiple Sclerosis
Disoder ID:
Synonyms:
PPMS,Primary-progressive MS
Definition:
A multiple sclerosis that is characterized by steady worsening of neurologic functioning, without any distinct relapses or periods of remission. The rate of progression may vary over time, with occasional plateaus or temporary improvements, but the progression is continuous.
Modifier statisitcs
Record:
1
Gene:
1
Variant:
1
Reference:
1
Effect type:
Expressivity(1)
Modifier effect:
Risk factor(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| CTLA4 | CTLA4:c.+49A/G(p.Thr17Ala) | Expressivity | Risk factor | OR=1.36; 95% CI: 1.11-1.81; P=0.038 | The CTLA4 +49 A/G and 3'UTR polymorphisms as potential modifiers of disease course in MS.more | more |
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