Disorder "Schizophrenia"
Found 4 records
Disorder information
Disorder name:
Schizophrenia 
Disoder ID:
OMIM entry:
Synonyms:
schizophrenia-1 
Definition:
A mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social or occupational dysfunction. The onset of symptoms typically occurs in young adulthood, with a global lifetime prevalence of about 0.3-0.7%. 
Modifier statisitcs
Record:
Gene:
Variant:
Reference:
Effect type:
Expressivity(4)  
Modifier effect:
Altered brain acitivity(1) ,Altered gene activity(1) ,BOLD response(1) ,Risk factor(1)  
Modifier gene Variant Effect type Modifier effect Evidence Effect PubMed ID
HTR2A HTR2A:c.-1438A/G Expressivity  Risk factor  P<0.05  The 5-HT2A receptor gene is a modifier gene of schizophreniamore more
Haplotype Haplotype:(rs12364283, rs2283265, rs1076560) Expressivity  Altered brain acitivity  The TGG haplotype (rs12364283, rs2283265 and rs1076560) had opposite Effects on brain activity in patients and controls.  The three functional DRD2 variants modulate schizophrenia phenotypes possibly by modifying D2S/D2L ratios in the context of different total D2 densitymore more
DRD2 DRD2:rs1076560 Expressivity  Altered gene activity  Gg subjects showing higher % d2s mrna in prefrontal cortex than gt subjects (P=0.004)  The three functional DRD2 variants modulate schizophrenia phenotypes possibly by modifying D2S/D2L ratios in the context of different total D2 densitymore more
DRD2:rs12364283 Expressivity  BOLD response  P<0.005  The three functional DRD2 variants modulate schizophrenia phenotypes possibly by modifying D2S/D2L ratios in the context of different total D2 densitymore more
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