Disorder "Schizophrenia"
Found 4 records
Disorder information
Disorder name:
Schizophrenia
Disoder ID:
OMIM entry:
Synonyms:
schizophrenia-1
Definition:
A mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social or occupational dysfunction. The onset of symptoms typically occurs in young adulthood, with a global lifetime prevalence of about 0.3-0.7%.
Modifier statisitcs
Record:
4
Gene:
3
Variant:
4
Reference:
2
Effect type:
Expressivity(4)
Modifier effect:
Altered brain acitivity(1)
,Altered gene activity(1)
,BOLD response(1)
,Risk factor(1)
Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
---|---|---|---|---|---|---|
HTR2A | HTR2A:c.-1438A/G | Expressivity | Risk factor | P<0.05 | The 5-HT2A receptor gene is a modifier gene of schizophreniamore | more |
Haplotype | Haplotype:(rs12364283, rs2283265, rs1076560) | Expressivity | Altered brain acitivity | The TGG haplotype (rs12364283, rs2283265 and rs1076560) had opposite Effects on brain activity in patients and controls. | The three functional DRD2 variants modulate schizophrenia phenotypes possibly by modifying D2S/D2L ratios in the context of different total D2 densitymore | more |
DRD2 | DRD2:rs1076560 | Expressivity | Altered gene activity | Gg subjects showing higher % d2s mrna in prefrontal cortex than gt subjects (P=0.004) | The three functional DRD2 variants modulate schizophrenia phenotypes possibly by modifying D2S/D2L ratios in the context of different total D2 densitymore | more |
DRD2:rs12364283 | Expressivity | BOLD response | P<0.005 | The three functional DRD2 variants modulate schizophrenia phenotypes possibly by modifying D2S/D2L ratios in the context of different total D2 densitymore | more |
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