Disorder "Septic shock"
Found 1 record
Disorder information
Disorder name:
Septic shock
Disoder ID:
Definition:
Shock caused by infection; frequently caused by gram negative bacteria, although some cases have been caused by other bacteria, viruses, fungi, and protozoa; characterized by fever, chills, tachycardia, tachypnea, and hypotension. Shock is a state of acute circulatory failure characterized by persistent arterial hypotension despite adequate fluid resuscitation or by tissue hypoperfusion unexplained by other causes.
Modifier statisitcs
Record:
1
Gene:
1
Variant:
1
Reference:
1
Effect type:
Expressivity(1)
Modifier effect:
Altered life span(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| SVEP1 | SVEP1:rs10817033 | Expressivity | Altered life span | HR=1.72; 95% CI: 1.31-2.26; P=9.7×10(-5) | C allele of SVEP1 c.2080A>C has damaging effects on protein structure, was associated with increased 28-day mortality and organ dysfunction of septic shock.more | more |
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