Disorder "Thrombocytosis"
Found 1 record
Disorder information
Disorder name:
Thrombocytosis 
Disoder ID:
Synonyms:
Thrombocythaemia 
Definition:
Increased numbers of platelets in the peripheral blood. 
Modifier statisitcs
Record:
Gene:
Variant:
Reference:
Effect type:
Expressivity(1)  
Modifier effect:
Altered degree of myeloproliferation and myeloid metaplasia(1)  
Modifier gene Variant Effect type Modifier effect Evidence Effect PubMed ID
JAK2 JAK2:c.1641+779C>G Expressivity  Altered degree of myeloproliferation and myeloid metaplasia  P<0.03  The JAK2 V617F allele burden as a key determinant of the degree of myeloproliferation and myeloid metaplasia reflected by significantly higher levels of white blood cell counts (WBC)more more
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