Disorder "Thyroid Carcinoma"
Found 4 records
Disorder information
Disorder name:
Thyroid Carcinoma
Disoder ID:
Synonyms:
thyroid gland carcinoma, head and neck cancer, Thyroid
Definition:
The presence of a carcinoma of the thyroid gland.
Modifier statisitcs
Record:
4
Gene:
3
Variant:
4
Reference:
1
Effect type:
Expressivity(4)
Modifier effect:
Risk factor(4)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| XRCC1 | XRCC1:c.1196A>G(p.Gln399Arg) | Expressivity | Risk factor | OR=0.70, 95% CI: 0.59-0.93 | Polymorphisms of DNA damage response genes may be potential risk modifiers of ionizing radiation-induced or sporadic PTCs.more | more |
| TP53 | TP53:rs1042522 | Expressivity | Risk factor | OR=1.80, 95% CI: 1.06-2.36 | Polymorphisms of DNA damage response genes may be potential risk modifiers of ionizing radiation-induced or sporadic PTCs.more | more |
| ATM | ATM:c.5557G>A(p.Asp1853Asn) | Expressivity | Risk factor | OR=0.69, 95% CI: 0.45-0.86 | Polymorphisms of DNA damage response genes may be potential risk modifiers of ionizing radiation-induced or sporadic PTCs.more | more |
| ATM:c.IVS22-77T>C | Expressivity | Risk factor | OR=1.84, 95% CI: 1.10-3.24 | Polymorphisms of DNA damage response genes may be potential risk modifiers of ionizing radiation-induced or sporadic PTCs.more | more |
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