Disorder "Tropical Pancreatitis"
Found 3 records
Disorder information
Disorder name:
Tropical Pancreatitis
Disoder ID:
OMIM entry:
Synonyms:
TCP, Tropical calcific chronic pancreatitis
Definition:
Tropical pancreatitis is a rare pancreatic disease of juvenile onset occurring mainly in tropical developing countries and characterized by chronic non-alcoholic pancreatitis manifesting with abdominal pain, steatorrhea and fibrocalculous pancreatopathy (see this term). It is also commonly associated with the development of pancreatic calculi and pancreatic cancer at a much higher frequency than seen in ordinary chronic pancreatitis.
Modifier statisitcs
Record:
3
Gene:
1
Variant:
3
Reference:
1
Effect type:
Penetrance(3)
Modifier effect:
Altered incidence(3)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| CTSB | CTSB:c.157A>G(p.Ser53Gly) | Penetrance | Altered incidence | P=0.008 | These variants may be critical as a trigger for cationic trypsinogen activation.more | more |
| CTSB:c.76C>G(p.Leu26Val) | Penetrance | Altered incidence | OR=2.15, 95% CI: 1.60-2.90, P=0.009 | These variants may be critical as a trigger for cationic trypsinogen activation.more | more | |
| CTSB:c.C595T | Penetrance | Altered incidence | P=0.001 | These variants may be critical as a trigger for cationic trypsinogen activation.more | more |
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