Disorder "Carotid Stenosis"
Found 1 record
Disorder information
Disorder name:
Carotid Stenosis 
Disoder ID:
Synonyms:
Stenosis, carotid artery, Carotid artery stenosis 
Definition:
Carotid artery stenosis is a narrowing of the large arteries on either side of the neck that carry blood to the head, face and brain. This narrowing is usually the result of a build-up of plaque within the arteries, a condition called atherosclerosis. Stenosis can worsen over time to completely block the artery which may lead to stroke. 
Modifier statisitcs
Record:
Gene:
Variant:
Reference:
Effect type:
Expressivity(1)  
Modifier effect:
Risk factor(1)  
Modifier gene Variant Effect type Modifier effect Evidence Effect PubMed ID
APOA5 APOA5:c.-1131T>C Expressivity  Risk factor  OR=3.69, P<0.05  The C allele of the -1131T>C SNP in the APOA5 gene was associated with an increased risk for the development of carotid plaque in patientsmore more
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