Disorder "Congestive Heart Failure"
Found 7 records
Disorder information
Disorder name:
Congestive Heart Failure
Disoder ID:
Synonyms:
CHF,Cardiac Failure Congestive,Congestive heart disease,Weak heart
Definition:
The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction.
Modifier statisitcs
Record:
7
Gene:
3
Variant:
6
Reference:
2
Effect type:
Expressivity(7)
Modifier effect:
Risk factor(6)
,Altered response to drug(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| ADRB3 | ADRB3:c.190T>C(p.Trp64Arg) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more |
| ADRB2 | ADRB2:c.46A>G(p.Arg16Gly) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more |
| ADRB2:c.79C>G(p.Gln27Glu) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more | |
| ADRB2:T164I | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more | |
| ADRB1 | ADRB1:c.145A>G(p.Ser49Gly) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more |
| ADRB1:c.1165G>C(p.Gly389Arg) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more | |
| ADRB1:c.1165G>C(p.Gly389Arg) | Expressivity | Altered response to drug | From review article | Enhanced effects on Heart Failure endpoint event rate reductionmore | more |
Total 7,Each Page
,Jump To
Page