Disorder "Depressivity"
Found 3 records
Disorder information
Disorder name:
Depressivity
Disoder ID:
Synonyms:
Depression
Definition:
Frequent feelings of being down, miserable, and/or hopeless; difficulty recovering from such moods; pessimism about the future; pervasive shame; feeling of inferior self-worth; thoughts of suicide and suicidal behavior.
Modifier statisitcs
Record:
3
Gene:
2
Variant:
3
Reference:
1
Effect type:
Expressivity(3)
Modifier effect:
Risk factor(3)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| ESR2 | ESR2:c.984G>A(p.Val328Val) | Expressivity | Risk factor | OR=1.44, 95% CI: (1.01–2.05), P=0.05 | The ER-β rs4986938 polymorphism showed a weak association with depression risk.more | more |
| ESR1 | ESR1:c.453-351A>G | Expressivity | Risk factor | OR=0.60, 95% CI: (0.41–0.88), P=0.009 | The ER-α rs2234693 and rs9340799 polymorphisms were significantly associated with the risk of late-life depressionmore | more |
| ESR1:c.453-397T>C | Expressivity | Risk factor | OR=0.61, 95% CI: (0.44–0.84), P=0.003 | The ER-α rs2234693 and rs9340799 polymorphisms were significantly associated with the risk of late-life depressionmore | more |
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