Variant "LRRK2:rs34637584"
Search result: 1 record
Variant information
Gene:
LRRK2 
Variant:
LRRK2:rs34637584 
dbSNP ID:
rs34637584  
GWAS trait:
Parkinson's disease 
Modifier statisitcs
Record:
1 
Disorder:
1 
Reference:
1 
Effect type:
Penetrance(1)  
Modifier effect:
Altered incidence(1)  
Detail：
  • Target disease:
    Parkinson's disease (DOID_14330)
    Effect type:
    Penetrance 
    Modifier effect:
    Altered incidence 
    Evidence:
    From review article 
    Effect:
    Age-related penetrance for the most common LRRK2 Gly2019Ser mutation can range from ~30% to 70%
    Reference:
    PMID29977663
    Title:
    Genetic Modifiers in Neurodegeneration.
    Species studied:
    Human
    Abstract:
    To review the evidence for genetic modifier effects in the neurodegenerative diseases Huntington's Disease (HD), Frontotemporal Lobar Degeneration (FTLD), Alzheimer's Disease (AD), and Parkinson's Disease (PD).