Variant "NFKB1:c.-94ins/delATTG"
Search result: 1 record
Variant information
Gene:
NFKB1 
Variant:
NFKB1:c.-94ins/delATTG 
dbSNP ID:
no data 
GWAS trait:
no data 
Modifier statisitcs
Record:
1 
Disorder:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Risk factor(1)  
Detail：
  • Target disease:
    Colorectal Cancer (DOID_9256)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor 
    Evidence:
    OR=1.71; 95% CI: 1.23-2.38 
    Effect:
    NFκB1 and NFκBIA polymorphisms appear to jointly contribute to risk of CRC.
    Reference:
    PMID21738780
    Title:
    NFκB1 and NFκBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese population.
    Species studied:
    Human
    Abstract:
    Nuclear factor κB (NFκB) plays a key role in the regulation of apoptosis. The function of NFκB is inhibited by binding to NFκB inhibitor (IκB), and disruption of the balance of NFκB and IκB is related to the development of many diseases, including tumors. Therefore, we hypothesized that the NFκB1 (-94del/insATTG) and NFκBIA (2758 A>G) polymorphisms were associated with colorectal cancer (CRC) susceptibility.