Variant "BCLAF1:c.-115+1501G>A"
Search result: 1 record
Variant information
Gene:
BCLAF1 
Variant:
BCLAF1:c.-115+1501G>A 
Genomic location:
chr6:136609350(hg19) 
HGVS:
SO Term RefSeq
protein_coding NM_014739.2:c.-115+1501G>A
protein_coding NM_001077440.1:c.-115+1501G>A
protein_coding NM_001077441.1:c.-115+1501G>A
protein_coding NM_001301038.1:c.-115+1501G>A
dbSNP ID:
rs703193  
GWAS trait:
no data 
Modifier statisitcs
Record:
1 
Disorder:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Altered baseline HbF level(1)  
Detail：
  • Target disease:
    Sickle Cell Anemia (DOID_10923)
    Effect type:
    Expressivity 
    Modifier effect:
    Altered baseline HbF level 
    Evidence:
    P<0.05 
    Effect:
    The polymorphisms may harbor trans-acting elements that help modulate baseline HbF level in sickle cell anemia.
    Reference:
    PMID15040424
    Title:
    Polymorphisms near a chromosome 6q QTL area are associated with modulation of fetal hemoglobin levels in sickle cell anemia.
    Species studied:
    Human
    Abstract:
    In patients with sickle cell anemia, fetal hemoglobin (HbF) concentrations vary by 2 orders of magnitude. This variance may be a result of heterogeneity in gene regulatory elements; accordingly, we searched for single nucleotide polymorphisms (SNPs) that might identify this variation. More than 180 SNPs were studied in 38 genes in 280 sickle cell anemia patients. The strongest association with HbF was found with SNPs near a QTL previously localized on chromosome 6q22.3-q23.2. Initially, two SNPs were identified in intergenic portions of this QTL and were associated with about a 20% difference in percent HbF. Subsequently, we genotyped 44 additional SNPs in the genomic region between 136.1 Mb and 137.5 Mb on chromosome 6q. Twelve SNPs, associated with a 20%-30% difference in HbF concentrations, were located in the introns of four genes, PDE7B, MAP7, MAP3K5 and PEX7. In K562 cells, the p38-MAPK pathway has been associated with the activation of gamma-globin gene expression by histone deacetylase inhibitors. Haplotypes C-T-T-T in MAP7 and T-C-C in PEX7 were significantly associated with increases in concentration of HbF, both showing strong dominance. Genetic elements abutting the 6q22.3-q23.2 QTL, may harbor trans-acting elements that help modulate baseline HbF level in sickle cell anemia.