Variant "DAOA:c.89G>A(p.Arg30Lys)"
Search result: 1 record
Variant information
Gene:
DAOA 
Variant:
DAOA:c.89G>A(p.Arg30Lys) 
Genomic location:
chr13:106119446(hg19) 
HGVS:
SO Term RefSeq
protein_coding NM_172370.4:c.89G>A(p.Arg30Lys)
protein_coding NM_001161814.1:c.-125G>A
protein_coding NM_001161812.1:c.-105G>A
pseudogene NR_040247.1:n.506-677C>T
dbSNP ID:
rs2391191  
GWAS trait:
no data 
Modifier statisitcs
Record:
1 
Disorder:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Risk factor(1)  
Detail：
  • Target disease:
    Alzheimer's Disease (DOID_10652)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor 
    Evidence:
    P=1.94×10(-4), P(FDR)=9.34×10(-3) 
    Effect:
    Polymorphisms in the DAOA gene are linked to the occurrence of neuropsychiatric symptoms such as depression, apathy, aggression, delusions, hallucinations, and psychosis in AD.
    Reference:
    PMID26949549
    Title:
    A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer's Disease.
    Species studied:
    Human
    Abstract:
    We previously reported age of onset (AOO) modifier genes in the world's largest pedigree segregating early-onset Alzheimer's disease (AD), caused by the p.Glu280Ala (E280A) mutation in the PSEN1 gene. Here we report the results of a targeted analysis of functional exonic variants in those AOO modifier genes in sixty individuals with PSEN1 E280A AD who were whole-exome genotyped for ~250,000 variants. Standard quality control, filtering, and annotation for functional variants were applied, and common functional variants located in those previously reported as AOO modifier loci were selected. Multiloci linear mixed-effects models were used to test the association between these variants and AOO. An exonic missense mutation in the G72 (DAOA) gene (rs2391191, P = 1.94 × 10(-4), P FDR = 9.34 × 10(-3)) was found to modify AOO in PSEN1 E280A AD. Nominal associations of missense mutations in the CLUAP1 (rs9790, P = 7.63 × 10(-3), P FDR = 0.1832) and EXOC2 (rs17136239, P = 0.0325, P FDR = 0.391) genes were also found. Previous studies have linked polymorphisms in the DAOA gene with the occurrence of neuropsychiatric symptoms such as depression, apathy, aggression, delusions, hallucinations, and psychosis in AD. Our findings strongly suggest that this new conspicuous functional AOO modifier within the G72 (DAOA) gene could be pivotal for understanding the genetic basis of AD.