Variant "Haplotype:(TNF:c.-308G>A,IL10:c.-1082A>G)"
Search result: 1 record
Variant information
Gene:
Haplotype 
Variant:
Haplotype:(TNF:c.-308G>A,IL10:c.-1082A>G) 
dbSNP ID:
no data 
GWAS trait:
no data 
Modifier statisitcs
Record:
1 
Disorder:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Risk factor(1)  
Detail：
  • Target disease:
    Systemic Lupus Erythematosus (DOID_9074)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor 
    Evidence:
    P=0.006 
    Effect:
    The combinatorial complexity of TNFA and IL10 promoter polymorphisms impacts SLE susceptibility.
    Reference:
    PMID29298134
    Title:
    The Synergistic Effect of TNFA and IL10 Promoter Polymorphisms on Genetic Predisposition to Systemic Lupus Erythematosus.
    Species studied:
    Human
    Abstract:
    We investigated the individual and combined effect of functional TNFA -308G/A and IL10 -1082G/A single nucleotide polymorphisms (SNPs) and their genotypes on the susceptibility to systemic lupus erythematosus (SLE) in a Bulgarian population.