Due to Vincristine, Allele G is not connected with increase danger of Peripheral neuropathy for people with Precursor Cell Lymphoblastic Leukemia-Lymphoma.
(References:
Zgheib et al., Pharmacogenet Genomics, 2018
;
Data Source:
PharmGkb; DrugBank
)
- ID
- V000004
- Class
- Variation
- Xrefs
-
dbSNP:rs1045642
- GRCh37
-
chr7:87138645 A>G/T
- GRCh38
-
chr7:87509329 A>G/T
- Aliases
-
NC_000007.14:g.87509329A>CNC_000007.14:g.87509329A>GNC_000007.14:g.87509329A>TNC_000007.13:g.87138645A>CNC_000007.13:g.87138645A>GNC_000007.13:g.87138645A>TNG_011513.1:g.208920T>GNG_011513.1:g.208920T>CNG_011513.1:g.208920T>ANM_000927.5:c.3435T>GNM_000927.5:c.3435T>CNM_000927.5:c.3435T>ANM_000927.4:c.3435T>GNM_000927.4:c.3435T>CNM_000927.4:c.3435T>ANM_001348945.2:c.3645T>GNM_001348945.2:c.3645T>CNM_001348945.2:c.3645T>ANM_001348945.1:c.3645T>GNM_001348945.1:c.3645T>CNM_001348945.1:c.3645T>ANM_001348944.2:c.3435T>GNM_001348944.2:c.3435T>CNM_001348944.2:c.3435T>ANM_001348944.1:c.3435T>GNM_001348944.1:c.3435T>CNM_001348944.1:c.3435T>ANM_001348946.2:c.3435T>GNM_001348946.2:c.3435T>CNM_001348946.2:c.3435T>ANM_001348946.1:c.3435T>GNM_001348946.1:c.3435T>CNM_001348946.1:c.3435T>ANP_000918.2:p.Ile1145MetNP_001335874.1:p.Ile1215MetNP_001335873.1:p.Ile1145MetNP_001335875.1:p.Ile1145Met|SEQ=[A/C/G/T]|LEN=1|GENE=ABCB1:5243
- Description
-
missense_variant,synonymous_variant,coding_sequence_variant
More
- ID
- D001646
- Class
- Disease
- Xrefs
-
MeSH:D054198
- Aliases
-
ALL, ChildhoodLymphocytic Leukemia, L1Childhood ALLLymphoblastic Leukemia, Acute, L2Leukemia, Lymphoblastic, Acute, L2Lymphocytic Leukemia, L2L2 Lymphocytic LeukemiaLeukemia, L2 LymphocyticL1 Lymphocytic LeukemiaLeukemia, Lymphoblastic, Acute, Philadelphia-PositiveLymphoblastic Leukemia, Acute, AdultLeukemia, Lymphoblastic, Acute, L1Leukemia, Lymphocytic, Acute, L2Lymphoblastic Leukemia, Acute, L1Leukemia, Lymphocytic, Acute, L1Lymphoblastic Leukemia, Acute, ChildhoodLeukemia, L1 Lymphocytic
- Description
-
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
More
- ID
- C000449
- Class
- Drug
- Xrefs
-
DrugBank:DB00541
- Aliases
-
22-OxovincaleukoblastinLeurocristine
- Description
-
Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
More
- ID
- P001216
- Class
- Phenotype
- Xrefs
-
MeSH:D010523
- Description
-
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
More
