Drug Mechanism

PD0168298

Methotrexate is associated with decrease expression of UGT1A8. (References: de Almagro et al., Biochem Pharmacol, 2011 ; Data Source: The Comparative Toxicogenomics Database(CTD) )

Methotrexate
ID
C000469
Class
Drug
Xrefs
DrugBank:DB00563
Aliases
4-amino-10-methylfolic acid4-amino-N(10)-methylpteroylglutamic acidAmethopterinMTXN-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Description
This compound belongs to the class of organic compounds known as glutamic acid and derivatives. These are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. More
UGT1A8
ID
G001739
Class
Gene
Xrefs
HGNC:12540
Aliases
UGT1H
Description
UDP glucuronosyltransferase family 1 member A8 More