Curcumin

Basic Information

CAS ID: 458-37-7
Molecular Formula: C21H20O6
Molecular Weight: 368.4 g/mol
Monoisotopic Mass: 368.126 g/mol
Class: Small Molecule
Natural Product: Yes
Other Names: [13C]-Curcumin
Analysis: Drug repositioning mechanism analysis

O O O HO O OH

Compound Structure and Identifier

InChI: InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+ See All
InChI Key: VFLDPWHFBUODDF-FCXRPNKRSA-N
Smiles: COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O See All
Molfile: Download

Related Target

Related Fibrosis Property

Reference Record 1

PubMed ID 28188823 Target ID
Uniprot ID Name
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSC activation
Process III
Mechanism

Reference Record 2

PubMed ID 27865778 Target ID
Uniprot ID Name
Model vitro,rat Fibrosis Disease Glial scar
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting NF-κb and SOX9 signaling

Reference Record 3

PubMed ID 27829579 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III
Mechanism Targeting Akt/mTOR pathway

Reference Record 4

PubMed ID 27307790 Target ID
Uniprot ID Name
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 5

PubMed ID 24779927 Target ID
Uniprot ID Name
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting PPAR-γ

Reference Record 6

PubMed ID 24138392 Target ID
Uniprot ID Name
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation
Process III
Mechanism

Reference Record 7

PubMed ID 23317191 Target ID
Uniprot ID Name
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism Targeting miRNA-199 and miRNA-200

Reference Record 8

PubMed ID 16424149 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Cystic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 9

PubMed ID 16294327 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Pancreatic fibrosis
Process I attenue inflammation
Process II HSCs proliferation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 19474275 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 18705752 Target ID
Uniprot ID Name
Model rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 12

PubMed ID 18784349 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Pancreatic fibrosis
Process I
Process II cells proliferation
Process III
Mechanism Targeting ERK1/2 pathways

Trial Record 1

ClinicalTrial ID NCT02645656 Disease Submucous fibrosis
Phase Phase 2 Status Unknown
First Received January 5, 2016 Last Verified January 5, 2016
Sponsor SVS Institute of Dental Sciences

Trial Record 2

ClinicalTrial ID NCT02908152 Disease Liver fibrosis
Phase Phase 2,Phase 3 Status Unknown
First Received September 20, 2016 Last Verified September 20, 2016
Sponsor National Nutrition and Food Technology Institute

Related Link

PubChem: 969516
ChEMBL: CHEMBL140