| CAS ID: | 656247-17-5 |
| Molecular Formula: | C31H33N5O4 |
| Molecular Weight: | 539.6 g/mol |
| Monoisotopic Mass: | 539.2533 g/mol |
| Class: | Small Molecule |
| Natural Product: | No |
| Other Names: | OFEV | NINTEDANIB | Vargatef | BIBF 1120 | NINTEDANIB ESYLATE | BIBF-1120 |
| Analysis: | Drug repositioning mechanism analysis |
| InChI: | InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28- | See All |
| InChI Key: | XZXHXSATPCNXJR-ZIADKAODSA-N | |
| Smiles: | COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN4CCN(C)CC4)/c5ccccc5)\C(=O)Nc2c1 | See All |
| Molfile: | Download |
Reference Record 1
| PubMed ID | 29152045 | Target ID | |
| Uniprot ID | Name | ||
| Model | mice,rat,dog | Fibrosis Disease | Idiopathic pulmonary fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Reference Record 2
| PubMed ID | 26940352 | Target ID | |
| Uniprot ID | Name | ||
| Model | human | Fibrosis Disease | Idiopathic pulmonary fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Trial Record 1
| ClinicalTrial ID | NCT01170065 | Disease | Pulmonary fibrosis |
| Phase | Phase 2 | Status | Completed |
| First Received | July 27, 2010 | Last Verified | March 3, 2017 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 2
| ClinicalTrial ID | NCT01335464 | Disease | Pulmonary fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | April 14, 2011 | Last Verified | July 25, 2016 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 3
| ClinicalTrial ID | NCT01335477 | Disease | Pulmonary fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | April 14, 2011 | Last Verified | July 25, 2016 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 4
| ClinicalTrial ID | NCT00514683 | Disease | Pulmonary fibrosis |
| Phase | Phase 2 | Status | Completed |
| First Received | August 10, 2007 | Last Verified | January 6, 2015 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 5
| ClinicalTrial ID | NCT02230982 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Status | - | |
| First Received | September 3, 2014 | Last Verified | February 8, 2019 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 6
| ClinicalTrial ID | NCT02171156 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Status | - | |
| First Received | June 24, 2014 | Last Verified | May 8, 2017 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 7
| ClinicalTrial ID | NCT01619085 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Phase 3 | Status | Active, not recruiting |
| First Received | June 14, 2012 | Last Verified | January 30, 2019 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 8
| ClinicalTrial ID | NCT02598193 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Phase 4 | Status | Completed |
| First Received | November 5, 2015 | Last Verified | June 13, 2018 |
| Sponsor | Hoffmann-La Roche | ||
Trial Record 9
| ClinicalTrial ID | NCT01979952 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | November 8, 2013 | Last Verified | April 17, 2018 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 10
| ClinicalTrial ID | NCT02788474 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Phase 4 | Status | Completed |
| First Received | June 2, 2016 | Last Verified | June 20, 2018 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 11
| ClinicalTrial ID | NCT02802345 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | June 16, 2016 | Last Verified | January 11, 2019 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 12
| ClinicalTrial ID | NCT01417156 | Disease | Pulmonary fibrosis |
| Phase | Phase 2 | Status | Completed |
| First Received | August 16, 2011 | Last Verified | March 6, 2017 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 13
| ClinicalTrial ID | NCT02551068 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Not Applicable | Status | Recruiting |
| First Received | September 16, 2015 | Last Verified | October 26, 2018 |
| Sponsor | University of British Columbia | ||
Trial Record 14
| ClinicalTrial ID | NCT02607722 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Status | Active, not recruiting | |
| First Received | November 18, 2015 | Last Verified | February 15, 2019 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 15
| ClinicalTrial ID | NCT02579603 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Phase 4 | Status | Completed |
| First Received | October 19, 2015 | Last Verified | February 13, 2018 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 16
| ClinicalTrial ID | NCT01136174 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Phase 2 | Status | Completed |
| First Received | June 3, 2010 | Last Verified | January 6, 2015 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 17
| ClinicalTrial ID | NCT03242759 | Disease | Pulmonary fibrosis |
| Phase | Status | Active, not recruiting | |
| First Received | August 8, 2017 | Last Verified | March 20, 2019 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 18
| ClinicalTrial ID | NCT02606877 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Phase 4 | Status | Completed |
| First Received | November 17, 2015 | Last Verified | March 4, 2019 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 19
| ClinicalTrial ID | NCT02597933 | Disease | Pulmonary fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | November 5, 2015 | Last Verified | December 7, 2018 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 20
| ClinicalTrial ID | NCT03047031 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Status | Recruiting | |
| First Received | February 8, 2017 | Last Verified | March 5, 2019 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 21
| ClinicalTrial ID | NCT03281200 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Status | Completed | |
| First Received | September 13, 2017 | Last Verified | June 8, 2018 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 22
| ClinicalTrial ID | NCT03313180 | Disease | Pulmonary fibrosis |
| Phase | Phase 3 | Status | Recruiting |
| First Received | October 18, 2017 | Last Verified | March 20, 2019 |
| Sponsor | Boehringer Ingelheim | ||
Trial Record 23
| ClinicalTrial ID | NCT03313180 | Disease | Pulmonary fibrosis |
| Phase | Phase 3 | Status | Recruiting |
| First Received | October 18, 2017 | Last Verified | March 20, 2019 |
| Sponsor | Boehringer Ingelheim | ||
| PubChem: | 9809715 |
| ChEMBL: | CHEMBL502835 |