N-acetylcysteine

Basic Information

CAS ID: 616-91-1
Molecular Formula: C5H9NO3S
Molecular Weight: 163.2 g/mol
Monoisotopic Mass: 163.0303 g/mol
Class: Small Molecule
Natural Product: No
Other Names: FLUIMUCIL LONG | MUCOSIL-10 | ACC-600 | ORONAC 600 | FLUIMUCIL 600 | 5052 | PARVOLEX | AIRBRON | ACETYLCYSTEINE | SIRAN | ILUBE | FLUIMUCIL | SOLMUCOL | YOURNAC | MUCOSIL | FLUIMUCIL N | CETYLEV | ACETADOTE | RESPI-NAC | MUCOSIL-20 | MUCOMYST | A-CYS | FABROL | EN-CYS | N-ACETYL-L-CYSTEINE
Analysis: Drug repositioning mechanism analysis

O NH HS O HO

Compound Structure and Identifier

InChI: InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1 See All
InChI Key: PWKSKIMOESPYIA-BYPYZUCNSA-N
Smiles: CC(=O)N[C@@H](CS)C(=O)O See All
Molfile: Download

Related Target

Related Fibrosis Property

Reference Record 1

PubMed ID 28455747 Target ID
Uniprot ID Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism Targeting ERK1/2 pathway

Reference Record 2

PubMed ID 24915841 Target ID
Uniprot ID Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II EMT,cells proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 20954832 Target ID
Uniprot ID Name
Model vitro,human Fibrosis Disease Cystic fibrosis
Process I
Process II
Process III
Mechanism Targeting myeloperoxidase

Trial Record 1

ClinicalTrial ID NCT00639496 Disease Pulmonary fibrosis
Phase Phase 3 Status Completed
First Received March 20, 2008 Last Verified March 5, 2015
Sponsor Zambon SpA

Trial Record 2

ClinicalTrial ID NCT00809094 Disease Cystic fibrosis
Phase Phase 2 Status Completed
First Received December 17, 2008 Last Verified April 22, 2013
Sponsor Stanford University

Trial Record 3

ClinicalTrial ID NCT02707640 Disease Idiopathic pulmonary fibrosis
Phase Phase 2 Status Completed
First Received March 14, 2016 Last Verified May 20, 2016
Sponsor Hoffmann-La Roche

Trial Record 4

ClinicalTrial ID NCT00650091 Disease Pulmonary fibrosis
Phase Phase 3 Status Completed
First Received April 1, 2008 Last Verified June 2, 2015
Sponsor Duke University

Trial Record 5

ClinicalTrial ID NCT00996424 Disease Cystic fibrosis
Phase Phase 4 Status Terminated
First Received October 16, 2009 Last Verified August 15, 2011
Sponsor University Hospital, Ghent

Trial Record 6

ClinicalTrial ID NCT00467831 Disease Pulmonary fibrosis
Phase Phase 1,Phase 2 Status Terminated
First Received May 1, 2007 Last Verified August 2, 2013
Sponsor National Human Genome Research Institute (NHGRI)

Trial Record 7

ClinicalTrial ID NCT01111422 Disease Renal fibrosis
Phase Phase 4 Status Unknown
First Received April 27, 2010 Last Verified April 27, 2010
Sponsor Ewha Womans University

Related Link

PubChem: 12035
ChEMBL: CHEMBL600