Pirfenidone

Basic Information

CAS ID: 53179-13-8
Molecular Formula: C12H11NO
Molecular Weight: 185.2 g/mol
Monoisotopic Mass: 185.0841 g/mol
Class: Small Molecule
Natural Product: No
Other Names: AMR-69 | ESBRIET | PIRFENIDONE
Analysis: Drug repositioning mechanism analysis

N O

Compound Structure and Identifier

InChI: InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3 See All
InChI Key: ISWRGOKTTBVCFA-UHFFFAOYSA-N
Smiles: CC1=CN(C(=O)C=C1)c2ccccc2 See All
Molfile: Download

Related Target

Related Fibrosis Property

Reference Record 1

PubMed ID 28303974 Target ID
Uniprot ID Name
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 28148565 Target ID
Uniprot ID Name
Model vitro,human Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II
Process III
Mechanism Targeting GLI

Reference Record 3

PubMed ID 27616539 Target ID
Uniprot ID Name
Model human Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 4

PubMed ID 22550395 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Retinal fibrosis
Process I
Process II cells migration
Process III prevenet collagen deposition
Mechanism Targeting Smad2/3

Reference Record 5

PubMed ID 22342629 Target ID
Uniprot ID Name
Model Fibrosis Disease Fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 22339859 Target ID
Uniprot ID Name
Model Fibrosis Disease Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 7

PubMed ID 22301723 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 8

PubMed ID 17030685 Target ID
Uniprot ID Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 9

PubMed ID 29552620 Target ID
Uniprot ID Name
Model vitro,mice Fibrosis Disease Intestinal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 28933986 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Fibrosis
Process I
Process II cells proliferation,cells migration
Process III
Mechanism

Trial Record 1

ClinicalTrial ID NCT00020631 Disease Skin fibrosis
Phase Not Applicable Status Completed
First Received January 27, 2003 Last Verified June 19, 2013
Sponsor National Cancer Institute (NCI)

Trial Record 2

ClinicalTrial ID NCT00080223 Disease Idiopathic pulmonary fibrosis,Pulmonary fibrosis
Phase Phase 2 Status Completed
First Received March 26, 2004 Last Verified April 17, 2017
Sponsor Genentech, Inc.

Trial Record 3

ClinicalTrial ID NCT00662038 Disease Idiopathic pulmonary fibrosis
Phase Phase 3 Status Completed
First Received April 21, 2008 Last Verified March 29, 2017
Sponsor Genentech, Inc.

Trial Record 4

ClinicalTrial ID NCT02009293 Disease Idiopathic pulmonary fibrosis
Phase Status Completed
First Received December 11, 2013 Last Verified December 23, 2016
Sponsor Erasmus Medical Center

Trial Record 5

ClinicalTrial ID NCT02648048 Disease Idiopathic pulmonary fibrosis
Phase Phase 1 Status Completed
First Received January 6, 2016 Last Verified October 30, 2017
Sponsor Hoffmann-La Roche

Trial Record 6

ClinicalTrial ID NCT00287729 Disease Idiopathic pulmonary fibrosis
Phase Phase 3 Status Completed
First Received February 7, 2006 Last Verified April 17, 2017
Sponsor Genentech, Inc.

Trial Record 7

ClinicalTrial ID NCT00287716 Disease Idiopathic pulmonary fibrosis
Phase Phase 3 Status Completed
First Received February 7, 2006 Last Verified May 22, 2017
Sponsor Genentech, Inc.

Trial Record 8

ClinicalTrial ID NCT02871401 Disease Idiopathic pulmonary fibrosis
Phase Phase 1 Status Active, not recruiting
First Received August 18, 2016 Last Verified March 6, 2019
Sponsor Vanderbilt University Medical Center

Trial Record 9

ClinicalTrial ID NCT01872689 Disease Idiopathic pulmonary fibrosis
Phase Phase 2 Status Completed
First Received June 7, 2013 Last Verified August 24, 2018
Sponsor Hoffmann-La Roche

Trial Record 10

ClinicalTrial ID NCT02141087 Disease Idiopathic pulmonary fibrosis
Phase Status -
First Received May 19, 2014 Last Verified July 13, 2015
Sponsor Genentech, Inc.

Trial Record 11

ClinicalTrial ID NCT01504334 Disease Idiopathic pulmonary fibrosis
Phase Phase 2 Status Unknown
First Received January 5, 2012 Last Verified February 7, 2012
Sponsor Beijing Kawin Technology Share-Holding Co., Ltd.

Trial Record 12

ClinicalTrial ID NCT01366209 Disease Idiopathic pulmonary fibrosis
Phase Phase 3 Status Completed
First Received June 3, 2011 Last Verified April 5, 2017
Sponsor Genentech, Inc.

Trial Record 13

ClinicalTrial ID NCT02136992 Disease Idiopathic pulmonary fibrosis
Phase Phase 2 Status Completed
First Received May 13, 2014 Last Verified May 13, 2014
Sponsor Shanghai Pulmonary Hospital, Shanghai, China

Trial Record 14

ClinicalTrial ID NCT03208933 Disease Idiopathic pulmonary fibrosis
Phase Phase 3 Status Active, not recruiting
First Received July 6, 2017 Last Verified January 11, 2019
Sponsor Hoffmann-La Roche

Trial Record 15

ClinicalTrial ID NCT02598193 Disease Idiopathic pulmonary fibrosis
Phase Phase 4 Status Completed
First Received November 5, 2015 Last Verified June 13, 2018
Sponsor Hoffmann-La Roche

Trial Record 16

ClinicalTrial ID NCT02707640 Disease Idiopathic pulmonary fibrosis
Phase Phase 2 Status Completed
First Received March 14, 2016 Last Verified May 20, 2016
Sponsor Hoffmann-La Roche

Trial Record 17

ClinicalTrial ID NCT02951429 Disease Idiopathic pulmonary fibrosis
Phase Phase 2 Status Active, not recruiting
First Received November 1, 2016 Last Verified January 16, 2019
Sponsor Hoffmann-La Roche

Trial Record 18

ClinicalTrial ID NCT01417156 Disease Pulmonary fibrosis
Phase Phase 2 Status Completed
First Received August 16, 2011 Last Verified March 6, 2017
Sponsor Boehringer Ingelheim

Trial Record 19

ClinicalTrial ID NCT02699879 Disease Idiopathic pulmonary fibrosis
Phase Status Completed
First Received March 4, 2016 Last Verified April 21, 2017
Sponsor Hoffmann-La Roche

Trial Record 20

ClinicalTrial ID NCT02622477 Disease Idiopathic pulmonary fibrosis
Phase Status Completed
First Received December 4, 2015 Last Verified February 28, 2017
Sponsor Hoffmann-La Roche

Trial Record 21

ClinicalTrial ID NCT03115619 Disease Idiopathic pulmonary fibrosis
Phase Status Recruiting
First Received April 14, 2017 Last Verified January 11, 2019
Sponsor Hoffmann-La Roche

Trial Record 22

ClinicalTrial ID NCT02579603 Disease Idiopathic pulmonary fibrosis
Phase Phase 4 Status Completed
First Received October 19, 2015 Last Verified February 13, 2018
Sponsor Boehringer Ingelheim

Trial Record 23

ClinicalTrial ID NCT01136174 Disease Idiopathic pulmonary fibrosis
Phase Phase 2 Status Completed
First Received June 3, 2010 Last Verified January 6, 2015
Sponsor Boehringer Ingelheim

Trial Record 24

ClinicalTrial ID NCT03242759 Disease Pulmonary fibrosis
Phase Status Active, not recruiting
First Received August 8, 2017 Last Verified March 20, 2019
Sponsor Boehringer Ingelheim

Trial Record 25

ClinicalTrial ID NCT02606877 Disease Idiopathic pulmonary fibrosis
Phase Phase 4 Status Completed
First Received November 17, 2015 Last Verified March 4, 2019
Sponsor Boehringer Ingelheim

Trial Record 26

ClinicalTrial ID NCT02161952 Disease Liver fibrosis
Phase Phase 2 Status Completed
First Received June 12, 2014 Last Verified July 9, 2014
Sponsor University of Guadalajara

Trial Record 27

ClinicalTrial ID NCT02496182 Disease Pulmonary fibrosis
Phase Phase 2,Phase 3 Status Unknown
First Received July 14, 2015 Last Verified July 14, 2015
Sponsor Grupo Medifarma, S. A. de C. V.

Trial Record 28

ClinicalTrial ID NCT03068234 Disease Systemic sclerosis
Phase Phase 2,Phase 3 Status Not yet recruiting
First Received March 1, 2017 Last Verified March 1, 2017
Sponsor RenJi Hospital

Trial Record 29

ClinicalTrial ID NCT02408744 Disease Renal fibrosis
Phase Phase 1,Phase 2 Status Completed
First Received April 3, 2015 Last Verified April 3, 2015
Sponsor University of Guadalajara

Trial Record 30

ClinicalTrial ID NCT00001959 Disease Pulmonary fibrosis
Phase Phase 2 Status Completed
First Received January 19, 2000 Last Verified May 26, 2014
Sponsor National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Trial Record 31

ClinicalTrial ID NCT03260556 Disease Fibrosis
Phase Phase 4 Status Recruiting
First Received August 24, 2017 Last Verified September 28, 2017
Sponsor University of Cincinnati

Trial Record 32

ClinicalTrial ID NCT02823236 Disease Keloid
Phase Phase 3 Status Recruiting
First Received July 6, 2016 Last Verified July 14, 2017
Sponsor Centro Dermatológico Dr. Ladislao de la Pascua

Trial Record 33

ClinicalTrial ID NCT02932566 Disease Cardiac fibrosis
Phase Phase 2 Status Active, not recruiting
First Received October 13, 2016 Last Verified February 5, 2019
Sponsor Manchester University NHS Foundation Trust

Trial Record 34

ClinicalTrial ID NCT00011076 Disease Cardiac fibrosis
Phase Phase 2 Status Completed
First Received February 12, 2001 Last Verified March 4, 2008
Sponsor National Heart, Lung, and Blood Institute (NHLBI)

Trial Record 35

ClinicalTrial ID NCT03385668 Disease Pulmonary fibrosis
Phase Phase 2 Status Recruiting
First Received December 28, 2017 Last Verified March 19, 2018
Sponsor Assistance Publique - Hôpitaux de Paris

Trial Record 36

ClinicalTrial ID NCT03258801 Disease Idiopathic pulmonary fibrosis
Phase Status Recruiting
First Received August 23, 2017 Last Verified November 16, 2018
Sponsor Dr. Christopher Lambers

Related Link

PubChem: 40632
ChEMBL: CHEMBL1256391