Silmitasertib

Basic Information

CAS ID: 1009820-21-6
Molecular Formula: C19H12ClN3O2
Molecular Weight: 349.8 g/mol
Monoisotopic Mass: 349.0618 g/mol
Class: Small Molecule
Natural Product: No
Other Names: CX-4945 | Silmitasertib
Analysis: Drug repositioning mechanism analysis

OH O N NH Cl N

Compound Structure and Identifier

InChI: InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25) See All
InChI Key: MUOKSQABCJCOPU-UHFFFAOYSA-N
Smiles: OC(=O)c1ccc2c(c1)nc(Nc3cccc(Cl)c3)c4ccncc24 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0408 Casein kinase II subunit alpha inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 28133777 Target ID T0408
Uniprot ID Casein kinase II subunit alpha Name Casein kinase II subunit alpha
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSC activation
Process III prevenet collagen deposition
Mechanism Targeting TGF-β1 and NF-kB

Related Link

PubChem: 24748573
ChEMBL: CHEMBL1230165