| CAS ID: | 10236-47-2 |
| Molecular Formula: | C27H32O14 |
| Molecular Weight: | 580.5 g/mol |
| Monoisotopic Mass: | 580.1792 g/mol |
| Class: | Small Molecule |
| Natural Product: | Yes |
| Other Names: | Naringin |
| Analysis: | Drug repositioning mechanism analysis |
| InChI: | InChI=1S/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1 | See All |
| InChI Key: | DFPMSGMNTNDNHN-ZPHOTFPESA-N | |
| Smiles: | C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc3cc(O)c4C(=O)C[C@H](Oc4c3)c5ccc(O)cc5)[C@H](O)[C@H](O)[C@H]1O | See All |
| Molfile: | Download |
Reference Record 1
| PubMed ID | 27687505 | Target ID | |
| Uniprot ID | Name | ||
| Model | vitro,mice | Fibrosis Disease | Liver fibrosis |
| Process I | |||
| Process II | HSC activation | ||
| Process III | |||
| Mechanism | Targeting mTOR pathway | ||
Reference Record 2
| PubMed ID | 27174133 | Target ID | |
| Uniprot ID | Name | ||
| Model | rat | Fibrosis Disease | Cardiac fibrosis |
| Process I | |||
| Process II | |||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting TGF-β/Smad-3 and Nrf-2/HO-1 pathway | ||
Reference Record 3
| PubMed ID | 23603004 | Target ID | |
| Uniprot ID | Name | ||
| Model | mice | Fibrosis Disease | Pulmonary fibrosis |
| Process I | attenue inflammation | ||
| Process II | |||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||
| PubChem: | 442428 |
| ChEMBL: | CHEMBL451532 |