| CAS ID: | 78110-38-0 |
| Molecular Formula: | C13H17N5O8S2 |
| Molecular Weight: | 435.4 g/mol |
| Monoisotopic Mass: | 435.0519 g/mol |
| Class: | Small Molecule |
| Natural Product: | No |
| Other Names: | SO 26776 | AZTREONAM LYSINE | CAYSTON | SQ-26776 | Corus 1020 | AZTREONAM | Azactam |
| Analysis: | Drug repositioning mechanism analysis |
| InChI: | InChI=1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1 | See All |
| InChI Key: | WZPBZJONDBGPKJ-VEHQQRBSSA-N | |
| Smiles: | C[C@H]1[C@H](NC(=O)\C(=N/OC(C)(C)C(=O)O)\c2csc(N)n2)C(=O)N1S(=O)(=O)O | See All |
| Molfile: | Download |
Reference Record 1
| PubMed ID | 29089424 | Target ID | |
| Uniprot ID | Name | ||
| Model | mice | Fibrosis Disease | Cystic fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Reference Record 2
| PubMed ID | 27132188 | Target ID | |
| Uniprot ID | Name | ||
| Model | Fibrosis Disease | Cystic fibrosis | |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Reference Record 3
| PubMed ID | 17576827 | Target ID | |
| Uniprot ID | Name | ||
| Model | human | Fibrosis Disease | Cystic fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Trial Record 1
| ClinicalTrial ID | NCT00128492 | Disease | Cystic fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | August 10, 2005 | Last Verified | May 19, 2011 |
| Sponsor | Gilead Sciences | ||
Trial Record 2
| ClinicalTrial ID | NCT00104520 | Disease | Cystic fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | March 2, 2005 | Last Verified | March 11, 2011 |
| Sponsor | Gilead Sciences | ||
Trial Record 3
| ClinicalTrial ID | NCT01460836 | Disease | Cystic fibrosis |
| Phase | Status | Completed | |
| First Received | October 27, 2011 | Last Verified | October 27, 2011 |
| Sponsor | Novartis Pharmaceuticals | ||
Trial Record 4
| ClinicalTrial ID | NCT02730793 | Disease | Cystic fibrosis |
| Phase | Phase 2 | Status | Recruiting |
| First Received | April 6, 2016 | Last Verified | February 19, 2019 |
| Sponsor | Virginia Commonwealth University | ||
Trial Record 5
| ClinicalTrial ID | NCT00794586 | Disease | Cystic fibrosis |
| Phase | Phase 2 | Status | Completed |
| First Received | November 20, 2008 | Last Verified | December 27, 2013 |
| Sponsor | Gilead Sciences | ||
Trial Record 6
| ClinicalTrial ID | NCT00757237 | Disease | Cystic fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | September 23, 2008 | Last Verified | July 4, 2011 |
| Sponsor | Gilead Sciences | ||
Trial Record 7
| ClinicalTrial ID | NCT02449031 | Disease | Cystic fibrosis |
| Phase | Status | Active, not recruiting | |
| First Received | May 20, 2015 | Last Verified | January 4, 2019 |
| Sponsor | Mylan Inc. | ||
Trial Record 8
| ClinicalTrial ID | NCT01404234 | Disease | Cystic fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | July 28, 2011 | Last Verified | May 29, 2014 |
| Sponsor | Gilead Sciences | ||
Trial Record 9
| ClinicalTrial ID | NCT01059565 | Disease | Cystic fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | February 1, 2010 | Last Verified | March 11, 2014 |
| Sponsor | Gilead Sciences | ||
Trial Record 10
| ClinicalTrial ID | NCT01375049 | Disease | Cystic fibrosis |
| Phase | Phase 2 | Status | Completed |
| First Received | June 17, 2011 | Last Verified | July 17, 2014 |
| Sponsor | Gilead Sciences | ||
Trial Record 11
| ClinicalTrial ID | NCT01641822 | Disease | Cystic fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | July 17, 2012 | Last Verified | May 9, 2016 |
| Sponsor | Gilead Sciences | ||
Trial Record 12
| ClinicalTrial ID | NCT02894684 | Disease | Cystic fibrosis |
| Phase | Phase 4 | Status | Active, not recruiting |
| First Received | September 9, 2016 | Last Verified | August 21, 2018 |
| Sponsor | Liverpool Heart and Chest Hospital NHS Foundation Trust | ||
Trial Record 13
| ClinicalTrial ID | NCT00712166 | Disease | Cystic fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | July 9, 2008 | Last Verified | December 20, 2010 |
| Sponsor | Gilead Sciences | ||
Trial Record 14
| ClinicalTrial ID | NCT01055847 | Disease | Cystic fibrosis |
| Phase | Phase 2 | Status | Completed |
| First Received | January 26, 2010 | Last Verified | January 26, 2010 |
| Sponsor | Gilead Sciences | ||
Trial Record 15
| ClinicalTrial ID | NCT00112359 | Disease | Cystic fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | June 2, 2005 | Last Verified | April 21, 2011 |
| Sponsor | Gilead Sciences | ||
Trial Record 16
| ClinicalTrial ID | NCT01319253 | Disease | Cystic fibrosis |
| Phase | Status | Completed | |
| First Received | March 21, 2011 | Last Verified | November 6, 2015 |
| Sponsor | Indiana University | ||