| CAS ID: | 72558-82-8 |
| Molecular Formula: | C22H22N6O7S2 |
| Molecular Weight: | 546.6 g/mol |
| Monoisotopic Mass: | 546.0991 g/mol |
| Class: | Small Molecule |
| Natural Product: | No |
| Other Names: | Fortam | LY-139381 | GR 20263 | PENTACEF | Tazidime | Ceptaz | FORTAZ | TAZICEF | CEFTAZIDIME SODIUM | Ceftazidime (arginine formulation) | CEFTAZIDIME | Fortum | Kefazim |
| Analysis: | Drug repositioning mechanism analysis |
| InChI: | InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13-/t14-,18-/m1/s1 | See All |
| InChI Key: | ORFOPKXBNMVMKC-DWVKKRMSSA-N | |
| Smiles: | CC(C)(O\N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)[O-])C[n+]3ccccc3)\c4csc(N)n4)C(=O)O | See All |
| Molfile: | Download |
Reference Record 1
| PubMed ID | 27132188 | Target ID | |
| Uniprot ID | Name | ||
| Model | Fibrosis Disease | Cystic fibrosis | |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Reference Record 2
| PubMed ID | 20065059 | Target ID | |
| Uniprot ID | Name | ||
| Model | human | Fibrosis Disease | Cystic fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Reference Record 3
| PubMed ID | 17902147 | Target ID | |
| Uniprot ID | Name | ||
| Model | human | Fibrosis Disease | Cystic fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Reference Record 4
| PubMed ID | 16117983 | Target ID | |
| Uniprot ID | Name | ||
| Model | human | Fibrosis Disease | Cystic fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Trial Record 1
| ClinicalTrial ID | NCT02526004 | Disease | Cystic fibrosis |
| Phase | Not Applicable | Status | Unknown |
| First Received | August 18, 2015 | Last Verified | August 18, 2015 |
| Sponsor | University College Cork | ||
Trial Record 2
| ClinicalTrial ID | NCT01044719 | Disease | Cystic fibrosis |
| Phase | Phase 4 | Status | Unknown |
| First Received | January 8, 2010 | Last Verified | April 13, 2010 |
| Sponsor | Imperial College London | ||
Trial Record 3
| ClinicalTrial ID | NCT01667094 | Disease | Cystic fibrosis |
| Phase | Phase 4 | Status | Active, not recruiting |
| First Received | August 17, 2012 | Last Verified | April 20, 2017 |
| Sponsor | The Alfred | ||
Trial Record 4
| ClinicalTrial ID | NCT02840136 | Disease | Cystic fibrosis |
| Phase | Not Applicable | Status | Suspended |
| First Received | July 21, 2016 | Last Verified | June 13, 2018 |
| Sponsor | University Ghent | ||
Trial Record 5
| ClinicalTrial ID | NCT00418470 | Disease | Cystic fibrosis |
| Phase | Phase 4 | Status | Terminated |
| First Received | January 4, 2007 | Last Verified | October 29, 2015 |
| Sponsor | University of Florence | ||
Trial Record 6
| ClinicalTrial ID | NCT02504827 | Disease | Cystic fibrosis |
| Phase | Phase 4 | Status | Completed |
| First Received | July 22, 2015 | Last Verified | November 27, 2018 |
| Sponsor | University of Southern California | ||
Trial Record 7
| ClinicalTrial ID | NCT00153634 | Disease | Cystic fibrosis |
| Phase | Not Applicable | Status | Completed |
| First Received | September 12, 2005 | Last Verified | March 13, 2008 |
| Sponsor | Seattle Children's Hospital | ||
Trial Record 8
| ClinicalTrial ID | NCT00153634 | Disease | Cystic fibrosis |
| Phase | Not Applicable | Status | Completed |
| First Received | September 12, 2005 | Last Verified | March 13, 2008 |
| Sponsor | Seattle Children's Hospital | ||
Trial Record 9
| ClinicalTrial ID | NCT00823238 | Disease | Cystic fibrosis |
| Phase | Phase 1 | Status | Completed |
| First Received | January 15, 2009 | Last Verified | April 18, 2011 |
| Sponsor | University of North Carolina, Chapel Hill | ||
Trial Record 10
| ClinicalTrial ID | NCT00333385 | Disease | Cystic fibrosis |
| Phase | Phase 4 | Status | Terminated |
| First Received | June 5, 2006 | Last Verified | June 5, 2006 |
| Sponsor | Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche | ||
Trial Record 11
| ClinicalTrial ID | NCT01455246 | Disease | Liver fibrosis |
| Phase | Phase 2,Phase 3 | Status | Terminated |
| First Received | October 19, 2011 | Last Verified | October 15, 2014 |
| Sponsor | University of Padova | ||
| PubChem: | 57514439 |
| ChEMBL: | CHEMBL44354 |