| CAS ID: | 10102-43-9 |
| Molecular Formula: | NO |
| Molecular Weight: | 30 g/mol |
| Monoisotopic Mass: | 29.998 g/mol |
| Class: | Small Molecule |
| Natural Product: | No |
| Other Names: | NITRIC OXIDE | INOMAX |
| Analysis: | Drug repositioning mechanism analysis |
Reference Record 1
| PubMed ID | 17604059 | Target ID | |
| Uniprot ID | Name | ||
| Model | vitro | Fibrosis Disease | Cardiac fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | Targeting NF-κB | ||
Reference Record 2
| PubMed ID | 25641921 | Target ID | |
| Uniprot ID | Name | ||
| Model | rat | Fibrosis Disease | Liver fibrosis |
| Process I | |||
| Process II | HSCs activation,HSCs migration | ||
| Process III | |||
| Mechanism | |||
Trial Record 1
| ClinicalTrial ID | NCT00570349 | Disease | Cystic fibrosis |
| Phase | Phase 1,Phase 2 | Status | Completed |
| First Received | December 10, 2007 | Last Verified | June 16, 2016 |
| Sponsor | Mallinckrodt | ||
Trial Record 2
| ClinicalTrial ID | NCT01958944 | Disease | Cystic fibrosis |
| Phase | Phase 1,Phase 2 | Status | Completed |
| First Received | October 9, 2013 | Last Verified | June 3, 2016 |
| Sponsor | Advanced Inhalation Therapies Ltd | ||
Trial Record 3
| ClinicalTrial ID | NCT02498535 | Disease | Cystic fibrosis |
| Phase | Phase 2 | Status | Recruiting |
| First Received | July 15, 2015 | Last Verified | April 10, 2018 |
| Sponsor | Novoteris, LLC | ||
Trial Record 4
| ClinicalTrial ID | NCT03267108 | Disease | Pulmonary fibrosis |
| Phase | Phase 2 | Status | Recruiting |
| First Received | August 30, 2017 | Last Verified | January 10, 2019 |
| Sponsor | Bellerophon Pulse Technologies | ||
Trial Record 5
| ClinicalTrial ID | NCT02295566 | Disease | Cystic fibrosis |
| Phase | Phase 2 | Status | Completed |
| First Received | November 20, 2014 | Last Verified | November 20, 2014 |
| Sponsor | University Hospital Southampton NHS Foundation Trust | ||
Trial Record 6
| ClinicalTrial ID | NCT01265888 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Phase 2 | Status | Completed |
| First Received | December 23, 2010 | Last Verified | September 19, 2016 |
| Sponsor | Geno LLC | ||
Trial Record 7
| ClinicalTrial ID | NCT02267655 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Phase 1 | Status | Completed |
| First Received | October 17, 2014 | Last Verified | August 7, 2017 |
| Sponsor | Bellerophon | ||
Trial Record 8
| ClinicalTrial ID | NCT03135860 | Disease | Pulmonary fibrosis |
| Phase | Early Phase 1 | Status | Terminated |
| First Received | May 1, 2017 | Last Verified | September 18, 2017 |
| Sponsor | Bellerophon | ||
| PubChem: | 145068 |
| ChEMBL: | CHEMBL1200689 |