Amiloride

Basic Information

CAS ID: 2609-46-3
Molecular Formula: C6H8ClN7O
Molecular Weight: 229.6 g/mol
Monoisotopic Mass: 229.0479 g/mol
Class: Small Molecule
Natural Product: No
Other Names: BERKAMIL | AMILORIDE HYDROCHLORIDE | Amiloride | AMILAMONT | AMIPRAMIDINE | Hydro-Ride | AMORIDE | MIDAMOR | Midamor | AMILOSPARE 5
Analysis: Drug repositioning mechanism analysis

NH2 NH NH O N Cl NH2 N NH2

Compound Structure and Identifier

InChI: InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15) See All
InChI Key: XSDQTOBWRPYKKA-UHFFFAOYSA-N
Smiles: NC(=N)NC(=O)c1nc(Cl)c(N)nc1N See All
Molfile: Download

Related Target

Related Fibrosis Property

Reference Record 1

PubMed ID 19633071 Target ID
Uniprot ID Name
Model vitro,human,mice Fibrosis Disease Cystic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 2

PubMed ID 25371970 Target ID
Uniprot ID Name
Model vitro,rabbit Fibrosis Disease Scar
Process I
Process II
Process III
Mechanism

Trial Record 1

ClinicalTrial ID NCT00274391 Disease Cystic fibrosis
Phase Phase 2 Status Completed
First Received January 10, 2006 Last Verified January 10, 2006
Sponsor University of North Carolina

Trial Record 2

ClinicalTrial ID NCT00547053 Disease Cystic fibrosis
Phase Phase 1 Status Completed
First Received October 19, 2007 Last Verified May 13, 2011
Sponsor Boston Children’s Hospital

Trial Record 3

ClinicalTrial ID NCT00004705 Disease Cystic fibrosis
Phase Not Applicable Status Completed
First Received February 25, 2000 Last Verified March 25, 2015
Sponsor FDA Office of Orphan Products Development

Related Link

PubChem: 16231
ChEMBL: CHEMBL945