| CAS ID: | 564-25-0 |
| Molecular Formula: | C22H24N2O8 |
| Molecular Weight: | 444.4 g/mol |
| Monoisotopic Mass: | 444.1533 g/mol |
| Class: | Small Molecule |
| Natural Product: | No |
| Other Names: | DOXATET | DMSC | DOXYCHEL | Vibramycin | VIBRAMYCIN-D | DORYX | ACTICLATE CAP | ORACEA | VIBROX | NORDOX | DEMIX 100 | Vibramycin Hyclate | GS-3065 | VIBRA-TABS | DOXYCYCLINE HYCLATE | DOXYCHEL HYCLATE | DOXY-LEMMON | DOXYCYCLINE | Doryx | DOXY 100 | ATRIDOX | MONODOX | Doxy | DOXYLAR | DEMIX 50 | DOXYCYCLINE CALCIUM | PERIOSTAT | VIBRAMYCIN | DOXYCYCLINE HYDROCHLORIDE | VIBRAMYCIN 50 | DORYX MPC | ACTICLATE | Alodox | RAMYSIS | CYCLODOX | DOXYCYCLINE FOSFATEX | Vibra-Tabs | Doxy-Caps | Doxycycline Hydrochloride | AB08 | DOXY 200 | VIBRAMYCIN ACNE PACK |
| Analysis: | Drug repositioning mechanism analysis |
| InChI: | InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1 | See All |
| InChI Key: | JBIWCJUYHHGXTC-AKNGSSGZSA-N | |
| Smiles: | C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=C(C(=O)N)C(=O)[C@@]3(O)C(=C2C(=O)c4c(O)cccc14)O)O | See All |
| Molfile: | Download |
Reference Record 1
| PubMed ID | 11481479 | Target ID | |
| Uniprot ID | Name | ||
| Model | mice | Fibrosis Disease | Dermal fibrosis |
| Process I | |||
| Process II | |||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||
Reference Record 2
| PubMed ID | 21886950 | Target ID | |
| Uniprot ID | Name | ||
| Model | human | Fibrosis Disease | Idiopathic pulmonary fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | Targeting MMPs | ||
Trial Record 1
| ClinicalTrial ID | NCT01323101 | Disease | Cystic fibrosis |
| Phase | Phase 4 | Status | Completed |
| First Received | March 25, 2011 | Last Verified | March 30, 2017 |
| Sponsor | University of Southern California | ||
Trial Record 2
| ClinicalTrial ID | NCT01112059 | Disease | Cystic fibrosis |
| Phase | Not Applicable | Status | Completed |
| First Received | April 28, 2010 | Last Verified | March 6, 2017 |
| Sponsor | University of Alabama at Birmingham | ||
Trial Record 3
| ClinicalTrial ID | NCT02759120 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Phase 3 | Status | Recruiting |
| First Received | May 3, 2016 | Last Verified | January 21, 2019 |
| Sponsor | Weill Medical College of Cornell University | ||
Trial Record 4
| ClinicalTrial ID | NCT01594827 | Disease | Cystic fibrosis |
| Phase | Phase 2 | Status | Completed |
| First Received | May 9, 2012 | Last Verified | February 26, 2019 |
| Sponsor | Johns Hopkins University | ||
| PubChem: | 54671203 |
| ChEMBL: | CHEMBL1433 |