Riociguat

Basic Information

CAS ID: 625115-55-1
Molecular Formula: C20H19FN8O2
Molecular Weight: 422.4 g/mol
Monoisotopic Mass: 422.1615 g/mol
Class: Small Molecule
Natural Product: No
Other Names: BAY 63-2521 | ADEMPAS | RIOCIGUAT
Analysis: Drug repositioning mechanism analysis

O O N H2N N N NH2 N N F N

Compound Structure and Identifier

InChI: InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26) See All
InChI Key: WXXSNCNJFUAIDG-UHFFFAOYSA-N
Smiles: COC(=O)N(C)c1c(N)nc(nc1N)c2nn(Cc3ccccc3F)c4ncccc24 See All
Molfile: Download

Related Target

Target ID Name Interaction
T1026 Guanylate cyclase activator

Related Fibrosis Property

Reference Record 1

PubMed ID 20613628 Target ID T1026
Uniprot ID Guanylate cyclase Name Guanylate cyclase
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Trial Record 1

ClinicalTrial ID NCT02170025 Disease Cystic fibrosis
Phase Phase 2 Status Terminated
First Received June 23, 2014 Last Verified September 13, 2018
Sponsor Bayer

Trial Record 2

ClinicalTrial ID NCT02138825 Disease Pulmonary fibrosis
Phase Phase 2 Status Terminated
First Received May 15, 2014 Last Verified December 4, 2017
Sponsor Bayer

Related Link

PubChem: 11304743
ChEMBL: CHEMBL2107834