Verapamil

Basic Information

CAS ID:	52-53-9
Molecular Formula:	C27H38N2O4
Molecular Weight:	454.6 g/mol
Monoisotopic Mass:	454.2832 g/mol
Class:	Small Molecule
Natural Product:	No
Other Names:	CORDILOX MR 240 \| D-365 \| ZOLVERA \| SECURON MID \| RANVERA MR \| BERKATENS \| VERAPRESS MR 240 \| GEANGIN \| COVERA \| Covera-HS \| Calan \| MANIDON SR \| HALF SECURON SR \| CORDILOX I.V. \| CALAN SR \| CALAN \| [11C]-Verapamil \| IPROVERATRIL \| VERA-TIL SR \| SECURON SR \| SECURON IV \| ISOPTIN \| Verelan \| VERAPAMIL \| CP-16533-1 \| VERTAB SR 240 \| VERELAN PM \| UNIVER \| SECURON \| COVERA-HS \| CORDILOX \| Tarka \| Isoptin \| CP-16,533-1 \| ETHIMIL MR 240 \| VERELAN \| VERAPAMIL HYDROCHLORIDE \| Isoptin sr
Analysis:	Drug repositioning mechanism analysis

Compound Structure and Identifier

InChI:	InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3	See All
InChI Key:	SGTNSNPWRIOYBX-UHFFFAOYSA-N
Smiles:	COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC	See All
Molfile:	Download

Related Target

Target ID	Name	Interaction
T1066	L-type voltage-dependent Ca2+ channel	blocker

Related Fibrosis Property

Reference Record 1

PubMed ID	12937413	Target ID	T1066
Uniprot ID	L-type voltage-dependent Ca2+ channel	Name	L-type voltage-dependent Ca2+ channel
Model	mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	cells apoptosis
Process III	prevenet collagen deposition
Mechanism

Trial Record 1

ClinicalTrial ID	NCT01720056	Disease	Keloid
Phase	Phase 4	Status	Terminated
First Received	November 1, 2012	Last Verified	June 10, 2015
Sponsor	The University of Western Australia

Related Link

PubChem:	2520
ChEMBL:	CHEMBL6966