Sonidegib

Basic Information

CAS ID: 956697-53-3
Molecular Formula: C26H26F3N3O3
Molecular Weight: 485.5 g/mol
Monoisotopic Mass: 485.1926 g/mol
Class: Small Molecule
Natural Product: No
Other Names: ODOMZO | SONIDEGIB | LDE225 | ERISMODEGIB | SONIDEGIB PHOSPHATE
Analysis: Drug repositioning mechanism analysis

N O NH O O F F F N

Compound Structure and Identifier

InChI: InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+ See All
InChI Key: VZZJRYRQSPEMTK-CALCHBBNSA-N
Smiles: C[C@@H]1CN(C[C@H](C)O1)c2ccc(NC(=O)c3cccc(c3C)c4ccc(OC(F)(F)F)cc4)cn2 See All
Molfile: Download

Related Target

Target ID Name Interaction
T1059 Hedgehog inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 29147013 Target ID T1059
Uniprot ID Hedgehog Name Hedgehog
Model vitro,human,mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Trial Record 1

ClinicalTrial ID NCT02151864 Disease Liver fibrosis
Phase Phase 1 Status Completed
First Received May 30, 2014 Last Verified March 5, 2019
Sponsor Jason K. Sicklick, M.D.

Related Link

PubChem: 24775005
ChEMBL: CHEMBL2105737