Pentoxifylline

Basic Information

CAS ID: 6493-05-6
Molecular Formula: C13H18N4O3
Molecular Weight: 278.3 g/mol
Monoisotopic Mass: 278.1379 g/mol
Class: Small Molecule
Natural Product: No
Other Names: PENTOXIFYLLINE | TRENTAL | TRENTAL 400 | BL 191 | PENTOXIL | TRENTAL 100 | OXPENTIFYLLINE | NEOTREN MR
Analysis: Drug repositioning mechanism analysis

N O N O O N N

Compound Structure and Identifier

InChI: InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3 See All
InChI Key: BYPFEZZEUUWMEJ-UHFFFAOYSA-N
Smiles: CN1C(=O)N(CCCCC(=O)C)C(=O)c2c1ncn2C See All
Molfile: Download

Related Target

Related Fibrosis Property

Reference Record 1

PubMed ID 17678645 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 27376806 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism Targeting hedgehog signaling pathway

Trial Record 1

ClinicalTrial ID NCT00583700 Disease Fibrosis
Phase Phase 2 Status Completed
First Received December 31, 2007 Last Verified January 29, 2013
Sponsor University of Iowa

Trial Record 2

ClinicalTrial ID NCT01822405 Disease Skin fibrosis
Phase Phase 2 Status Unknown
First Received April 2, 2013 Last Verified April 2, 2013
Sponsor Hospital Universitario de Canarias

Trial Record 3

ClinicalTrial ID NCT00001437 Disease Skin fibrosis
Phase Phase 2 Status Completed
First Received December 10, 2002 Last Verified March 4, 2008
Sponsor National Cancer Institute (NCI)

Trial Record 4

ClinicalTrial ID NCT02898376 Disease Fibrosis
Phase Phase 3 Status Not yet recruiting
First Received September 13, 2016 Last Verified August 8, 2018
Sponsor Institut de Cancérologie de Lorraine

Trial Record 5

ClinicalTrial ID NCT00119119 Disease Liver fibrosis
Phase Phase 3 Status Terminated
First Received July 13, 2005 Last Verified January 12, 2007
Sponsor French National Agency for Research on AIDS and Viral Hepatitis

Trial Record 6

ClinicalTrial ID NCT02231333 Disease Liver fibrosis
Phase Not Applicable Status Unknown
First Received September 4, 2014 Last Verified March 24, 2015
Sponsor Institute of Liver and Biliary Sciences, India

Trial Record 7

ClinicalTrial ID NCT00022204 Disease Pulmonary fibrosis
Phase Phase 2 Status Completed
First Received February 4, 2004 Last Verified November 6, 2013
Sponsor Royal Marsden NHS Foundation Trust

Trial Record 8

ClinicalTrial ID NCT01249092 Disease Liver fibrosis
Phase Phase 2 Status Completed
First Received November 29, 2010 Last Verified December 9, 2013
Sponsor The Cleveland Clinic

Trial Record 9

ClinicalTrial ID NCT00162552 Disease Liver fibrosis
Phase Phase 3 Status Completed
First Received September 13, 2005 Last Verified January 17, 2008
Sponsor Assistance Publique - Hôpitaux de Paris

Trial Record 10

ClinicalTrial ID NCT02008214 Disease Liver fibrosis
Phase Phase 4 Status Unknown
First Received December 11, 2013 Last Verified December 11, 2013
Sponsor Centro Universitario de Ciencias de la Salud, Mexico

Trial Record 11

ClinicalTrial ID NCT01774487 Disease Liver fibrosis
Phase Phase 2 Status Recruiting
First Received January 24, 2013 Last Verified September 14, 2017
Sponsor Baylor College of Medicine

Related Link

PubChem: 4740
ChEMBL: CHEMBL628