Trichostatin A

Basic Information

CAS ID: 58880-19-6
Molecular Formula: C17H22N2O3
Molecular Weight: 302.4 g/mol
Monoisotopic Mass: 302.163 g/mol
Class: Small Molecule
Natural Product: No
Other Names:
Analysis: Drug repositioning mechanism analysis

O NH HO O N

Compound Structure and Identifier

InChI: InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1 See All
InChI Key: RTKIYFITIVXBLE-QEQCGCAPSA-N
Smiles: CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C See All
Molfile: Download

Related Target

Target ID Name Interaction
T0956 class I HDAC inhibitor
T0957 class II HDAC inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 26151196 Target ID T0956
Uniprot ID class I HDAC Name class I HDAC
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II EMT
Process III
Mechanism

Reference Record 2

PubMed ID 26151196 Target ID T0957
Uniprot ID class II HDAC Name class II HDAC
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II EMT
Process III
Mechanism

Reference Record 3

PubMed ID 19404935 Target ID
Uniprot ID Name
Model vitro,human Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 17610967 Target ID T0956
Uniprot ID class I HDAC Name class I HDAC
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II myofibroblasts differentiation
Process III
Mechanism

Reference Record 5

PubMed ID 17610967 Target ID T0957
Uniprot ID class II HDAC Name class II HDAC
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II myofibroblasts differentiation
Process III
Mechanism

Reference Record 6

PubMed ID 23707763 Target ID
Uniprot ID Name
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem: 444732
ChEMBL: