Guanabenz

Basic Information

CAS ID: 5051-62-7
Molecular Formula: C8H8Cl2N4
Molecular Weight: 231.1 g/mol
Monoisotopic Mass: 230.0126 g/mol
Class: Small Molecule
Natural Product: No
Other Names: Guanabenz | WY-8678 ACETATE | GUANABENZ ACETATE | WY-8678 | WYTENSIN
Analysis: Drug repositioning mechanism analysis

H2N NH NH N Cl Cl

Compound Structure and Identifier

InChI: InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+ See All
InChI Key: WDZVGELJXXEGPV-YIXHJXPBSA-N
Smiles: NC(=N)N\N=C\c1c(Cl)cccc1Cl See All
Molfile: Download

Related Target

Target ID Name Interaction
T0111 Alpha-2A adrenergic receptor agonist
T0112 Alpha-2B adrenergic receptor agonist

Related Fibrosis Property

Reference Record 1

PubMed ID 18640110 Target ID T0112
Uniprot ID Alpha-2B adrenergic receptor Name Alpha-2B adrenergic receptor
Model vitro Fibrosis Disease Cystic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 2

PubMed ID 18640110 Target ID T0111
Uniprot ID Alpha-2A adrenergic receptor Name Alpha-2A adrenergic receptor
Model vitro Fibrosis Disease Cystic fibrosis
Process I
Process II
Process III
Mechanism

Trial Record 1

ClinicalTrial ID NCT00597662 Disease Scar
Phase Phase 1 Status Completed
First Received January 18, 2008 Last Verified June 10, 2008
Sponsor University Hospital Tuebingen

Trial Record 2

ClinicalTrial ID NCT02133313 Disease Renal fibrosis
Phase Status Completed
First Received May 8, 2014 Last Verified April 19, 2017
Sponsor University of Alabama at Birmingham

Related Link

PubChem: 5702063
ChEMBL: CHEMBL420