| CAS ID: | 59-05-2 |
| Molecular Formula: | C20H22N8O5 |
| Molecular Weight: | 454.5 g/mol |
| Monoisotopic Mass: | 454.1713 g/mol |
| Class: | Small Molecule |
| Natural Product: | No |
| Other Names: | METHOTREXATE SODIUM | Amethopterin | ABITREXATE | MAXTREX | Trexall | OTREXUP | MEXATE | METOJECT | METHYLAMINOPTERIN | Abitrexate | XATMEP | MEXATE-AQ PRESERVED | methotrexate | OTREXUP PFS | EMTEXATE HIGH-POT | METHOTREXATE LPF | FOLEX | METHOTREXATE SODIUM PRESERVATIVE FREE | MEXATE-AQ | METHOTREXATE PRESERVATIVE FREE | RHEUMATREX | RASUVO | Folex | ZLATAL | EBETREX | FOLEX PFS | Mexate-AQ | EMTEXATE PF | CL 14377 | TREXALL |
| Analysis: | Drug repositioning mechanism analysis |
| InChI: | InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1 | See All |
| InChI Key: | FBOZXECLQNJBKD-ZDUSSCGKSA-N | |
| Smiles: | CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O | See All |
| Molfile: | Download |
Trial Record 1
| ClinicalTrial ID | NCT01240850 | Disease | Retroperitoneal fibrosis |
| Phase | Phase 3 | Status | Unknown |
| First Received | November 15, 2010 | Last Verified | November 15, 2010 |
| Sponsor | University of Parma | ||
Trial Record 2
| ClinicalTrial ID | NCT00006168 | Disease | Liver fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | August 9, 2000 | Last Verified | January 13, 2010 |
| Sponsor | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | ||
Trial Record 3
| ClinicalTrial ID | NCT00004784 | Disease | Liver fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | February 25, 2000 | Last Verified | June 24, 2005 |
| Sponsor | National Center for Research Resources (NCRR) | ||
Trial Record 4
| ClinicalTrial ID | NCT00004748 | Disease | Liver fibrosis |
| Phase | Phase 3 | Status | Completed |
| First Received | February 25, 2000 | Last Verified | June 24, 2005 |
| Sponsor | National Center for Research Resources (NCRR) | ||
Trial Record 5
| ClinicalTrial ID | NCT00006054 | Disease | Fibrosis |
| Phase | Not Applicable | Status | Terminated |
| First Received | July 6, 2000 | Last Verified | October 15, 2009 |
| Sponsor | Fairview University Medical Center | ||
| PubChem: | 126941 |
| ChEMBL: | CHEMBL34259 |