| CAS ID: | 80621-81-4 |
| Molecular Formula: | C43H51N3O11 |
| Molecular Weight: | 785.9 g/mol |
| Monoisotopic Mass: | 785.3524 g/mol |
| Class: | Small Molecule |
| Natural Product: | No |
| Other Names: | TARGAXAN | XIFAXANTA | RIFAXIDIN | NORMIX | RIFAXIMIN | Rifacol | XIFAXAN |
| Analysis: | Drug repositioning mechanism analysis |
| InChI: | InChI=1S/C43H51N3O11/c1-19-14-16-46-28(18-19)44-32-29-30-37(50)25(7)40-31(29)41(52)43(9,57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18,20,22-24,27,35-36,39,48-51H,1-10H3,(H,45,53)/b12-11+,17-15+,21-13-/t20-,22+,23+,24+,27-,35-,36+,39+,43-/m0/s1 | See All |
| InChI Key: | NZCRJKRKKOLAOJ-XRCRFVBUSA-N | |
| Smiles: | CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)\C(=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(=O)C)[C@@H]1C)\C)c5c(nc6cc(C)ccn56)c4c3C2=O | See All |
| Molfile: | Download |
Trial Record 1
| ClinicalTrial ID | NCT01603108 | Disease | Liver fibrosis |
| Phase | Phase 2 | Status | Unknown |
| First Received | May 22, 2012 | Last Verified | April 22, 2016 |
| Sponsor | Columbia University | ||
Trial Record 2
| ClinicalTrial ID | NCT01654939 | Disease | Liver fibrosis |
| Phase | Phase 4 | Status | Withdrawn |
| First Received | August 1, 2012 | Last Verified | September 28, 2015 |
| Sponsor | Douglas T. Dieterich | ||
Trial Record 3
| ClinicalTrial ID | NCT03150459 | Disease | Liver fibrosis |
| Phase | Phase 2 | Status | Completed |
| First Received | May 12, 2017 | Last Verified | October 3, 2018 |
| Sponsor | Judit Pich | ||
Trial Record 4
| ClinicalTrial ID | NCT02190357 | Disease | Liver fibrosis |
| Phase | Phase 4 | Status | Recruiting |
| First Received | July 15, 2014 | Last Verified | September 14, 2016 |
| Sponsor | Shanghai Changzheng Hospital | ||
Trial Record 5
| ClinicalTrial ID | NCT02074280 | Disease | Liver fibrosis |
| Phase | Phase 4 | Status | Unknown |
| First Received | February 28, 2014 | Last Verified | February 28, 2014 |
| Sponsor | Shanghai Changzheng Hospital | ||
Trial Record 6
| ClinicalTrial ID | NCT01904409 | Disease | Liver fibrosis |
| Phase | Phase 2 | Status | Completed |
| First Received | July 22, 2013 | Last Verified | April 10, 2018 |
| Sponsor | Valeant Pharmaceuticals International, Inc. | ||
Trial Record 7
| ClinicalTrial ID | NCT02265484 | Disease | Liver fibrosis |
| Phase | Not Applicable | Status | Completed |
| First Received | October 16, 2014 | Last Verified | November 22, 2016 |
| Sponsor | Institute of Liver and Biliary Sciences, India | ||
Trial Record 8
| ClinicalTrial ID | NCT01842581 | Disease | Liver fibrosis |
| Phase | Phase 4 | Status | Completed |
| First Received | April 29, 2013 | Last Verified | April 27, 2017 |
| Sponsor | Valeant Pharmaceuticals International, Inc. | ||
Trial Record 9
| ClinicalTrial ID | NCT01769040 | Disease | Liver fibrosis |
| Phase | Phase 4 | Status | Completed |
| First Received | January 16, 2013 | Last Verified | January 20, 2016 |
| Sponsor | Copenhagen University Hospital, Hvidovre | ||
Trial Record 10
| ClinicalTrial ID | NCT00748904 | Disease | Liver fibrosis |
| Phase | Phase 4 | Status | Unknown |
| First Received | September 9, 2008 | Last Verified | January 4, 2011 |
| Sponsor | Weill Medical College of Cornell University | ||
Trial Record 11
| ClinicalTrial ID | NCT02439307 | Disease | Liver fibrosis |
| Phase | Not Applicable | Status | Recruiting |
| First Received | May 8, 2015 | Last Verified | April 12, 2017 |
| Sponsor | Coordinación de Investigación en Salud, Mexico | ||
Trial Record 12
| ClinicalTrial ID | NCT01897051 | Disease | Liver fibrosis |
| Phase | Phase 2,Phase 3 | Status | Unknown |
| First Received | July 11, 2013 | Last Verified | April 21, 2015 |
| Sponsor | Yonsei University | ||
Trial Record 13
| ClinicalTrial ID | NCT02019784 | Disease | Liver fibrosis |
| Phase | Phase 4 | Status | Completed |
| First Received | December 24, 2013 | Last Verified | November 11, 2016 |
| Sponsor | King's College Hospital NHS Trust | ||
Trial Record 14
| ClinicalTrial ID | NCT02508623 | Disease | Liver fibrosis |
| Phase | Phase 3 | Status | Unknown |
| First Received | July 27, 2015 | Last Verified | July 28, 2015 |
| Sponsor | University of Padua | ||
Trial Record 15
| ClinicalTrial ID | NCT02555293 | Disease | Liver fibrosis |
| Phase | Phase 2 | Status | Recruiting |
| First Received | September 21, 2015 | Last Verified | August 29, 2018 |
| Sponsor | RWTH Aachen University | ||
Trial Record 16
| ClinicalTrial ID | NCT00281502 | Disease | Liver fibrosis |
| Phase | Phase 2 | Status | Unknown |
| First Received | January 24, 2006 | Last Verified | November 5, 2010 |
| Sponsor | Weill Medical College of Cornell University | ||
Trial Record 17
| ClinicalTrial ID | NCT01951209 | Disease | Liver fibrosis |
| Phase | Not Applicable | Status | Active, not recruiting |
| First Received | September 26, 2013 | Last Verified | March 25, 2019 |
| Sponsor | David E. Kaplan, MD MSc | ||
| PubChem: | 6436173 |
| ChEMBL: | CHEMBL1617 |