| CAS ID: | 192725-17-0 |
| Molecular Formula: | C37H48N4O5 |
| Molecular Weight: | 628.8 g/mol |
| Monoisotopic Mass: | 628.3625 g/mol |
| Class: | Small Molecule |
| Natural Product: | No |
| Other Names: | A-157378.0 | Kaletra | A-157378-0 | ABT-378 | LOPINAVIR |
| Analysis: | Drug repositioning mechanism analysis |
| InChI: | InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1 | See All |
| InChI Key: | KJHKTHWMRKYKJE-SUGCFTRWSA-N | |
| Smiles: | CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)COc3c(C)cccc3C)Cc4ccccc4 | See All |
| Molfile: | Download |
Trial Record 1
| ClinicalTrial ID | NCT00023218 | Disease | Liver fibrosis |
| Phase | Not Applicable | Status | Withdrawn |
| First Received | August 31, 2001 | Last Verified | March 9, 2015 |
| Sponsor | National Institute of Allergy and Infectious Diseases (NIAID) | ||
Trial Record 2
| ClinicalTrial ID | NCT01614405 | Disease | Liver fibrosis |
| Phase | Not Applicable | Status | Completed |
| First Received | June 7, 2012 | Last Verified | December 2, 2015 |
| Sponsor | University of Alberta | ||
Trial Record 3
| ClinicalTrial ID | NCT00661349 | Disease | Liver fibrosis |
| Phase | Phase 4 | Status | Terminated |
| First Received | April 18, 2008 | Last Verified | April 23, 2009 |
| Sponsor | Germans Trias i Pujol Hospital | ||
Trial Record 4
| ClinicalTrial ID | NCT01908660 | Disease | Liver fibrosis |
| Phase | Status | Completed | |
| First Received | July 26, 2013 | Last Verified | November 11, 2015 |
| Sponsor | Valme University Hospital | ||