Transforming growth factor beta-1

Basic Information

Uniprot ID: P01137
Secondary ID: A8K792, Q9UCG4
Symbol: TGFB1
Other Name: TGFB,Latency-associated peptide,Transforming growth factor beta-1,LAP,TGF-beta-1
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Growth factor,Mitogen

Target Classification

Category I Category II Category III
Extracellular Growth factor and receptor TGF-beta superfamily

Related Compound

Target ID Name Interaction
D0922 TGF-b + FnEDA DVD-Ig inhibitor
D0931 1D11 antagonist
D0934 Anti-TGFβ antibody inhibitor
D0989 p17 antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID 28827403 Compound ID D0922
CAS Name TGF-b + FnEDA DVD-Ig
Model mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 27864286 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 27859294 Compound ID D0989
CAS Name p17
Model human,rabbit Fibrosis Disease Submucosal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 27379382 Compound ID D0934
CAS Name Anti-TGFβ antibody
Model vitro,rat Fibrosis Disease Renal fibrosis
Process I
Process II myofibroblasts accumulation
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 24338442 Compound ID
CAS Name
Model vitro Fibrosis Disease Fibrosis
Process I
Process II EMT
Process III
Mechanism

Reference Record 6

PubMed ID 24282226 Compound ID
CAS Name
Model vitro Fibrosis Disease Corneal fibrosis
Process I
Process II fibroblasts migration
Process III
Mechanism

Reference Record 7

PubMed ID 22558184 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 22277325 Compound ID
CAS Name
Model rat Fibrosis Disease Bladder fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 22033267 Compound ID
CAS Name
Model mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 21600192 Compound ID
CAS Name
Model rat Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 21320502 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 12

PubMed ID 21195468 Compound ID
CAS Name
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III prevenet collagen deposition
Mechanism Targeting Smad3 and Smad7

Reference Record 13

PubMed ID 19734317 Compound ID
CAS Name
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 14

PubMed ID 19641518 Compound ID
CAS Name
Model vitro Fibrosis Disease Skin fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β/Smad/CTGF

Reference Record 15

PubMed ID 19502172 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II fibroblasts activation
Process III prevenet collagen deposition
Mechanism

Reference Record 16

PubMed ID 19374154 Compound ID
CAS Name
Model vitro Fibrosis Disease Vocal fold fibrosis
Process I
Process II cells migration
Process III prevenet collagen deposition
Mechanism

Reference Record 17

PubMed ID 16443218 Compound ID
CAS Name
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 18

PubMed ID 16036560 Compound ID
CAS Name
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 19

PubMed ID 15782092 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Pancreatic fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 20

PubMed ID 15194465 Compound ID
CAS Name
Model vitro Fibrosis Disease Fibrosis
Process I
Process II myofibroblasts differentiation
Process III
Mechanism Targeting ro-MT1-MMP and pro-MMP-2

Reference Record 21

PubMed ID 15117744 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 22

PubMed ID 14565855 Compound ID
CAS Name
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 23

PubMed ID 12114216 Compound ID
CAS Name
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 24

PubMed ID 17947678 Compound ID
CAS Name
Model rat Fibrosis Disease Subpleural fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 25

PubMed ID 17164399 Compound ID D0931
CAS Name 1D11
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III
Mechanism

Reference Record 26

PubMed ID 11438473 Compound ID
CAS Name
Model vitro,pig Fibrosis Disease Skin fibrosis
Process I
Process II cells proliferation
Process III
Mechanism Targeting Smad2 and Smad3

Reference Record 27

PubMed ID 11413354 Compound ID
CAS Name
Model human Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 28

PubMed ID 11073825 Compound ID
CAS Name
Model vitro Fibrosis Disease Keloid
Process I
Process II cells apoptosis
Process III
Mechanism

Reference Record 29

PubMed ID 28932540 Compound ID
CAS Name
Model rat Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III
Mechanism