| Uniprot ID: | O60565 |
| Secondary ID: | Q52LV3, Q8N914, Q8N936 |
| Symbol: | GREM1 |
| Other Name: | CKTSF1B1,Cell proliferation-inducing gene 2 protein,Cysteine knot superfamily 1, BMP antagonist 1,DAN domain family member 2,Down-regulated in Mos-transformed cells protein,Increased in high glucose protein 2,IHG-2 |
| Class: | Single Protein |
| Type: | pro-fibrotic |
| Molecular Function: | Cytokine |
| Category I | Category II | Category III |
|---|---|---|
| Extracellular | Growth factor and receptor | TGF-beta superfamily |
Reference Record 1
| PubMed ID | 28467108 | Compound ID | |
| CAS | Name | ||
| Model | vitro,mice | Fibrosis Disease | Liver fibrosis |
| Process I | |||
| Process II | HSC activation | ||
| Process III | |||
| Mechanism | Targeting TGF-β signaling | ||
Reference Record 2
| PubMed ID | 23548835 | Compound ID | |
| CAS | Name | ||
| Model | vitro | Fibrosis Disease | Renal fibrosis |
| Process I | |||
| Process II | EMT | ||
| Process III | |||
| Mechanism | |||
Reference Record 3
| PubMed ID | 16816361 | Compound ID | |
| CAS | Name | ||
| Model | vitro | Fibrosis Disease | Idiopathic pulmonary fibrosis |
| Process I | |||
| Process II | EMT | ||
| Process III | |||
| Mechanism | |||