| Uniprot ID: | P18075 |
| Secondary ID: | Q9H512, Q9NTQ7 |
| Symbol: | BMP7 |
| Other Name: | OP1,BMP-7,Osteogenic protein 1,OP-1, |
| Class: | Single Protein |
| Type: | anti-fibrotic |
| Molecular Function: | Cytokine,Developmental protein,Growth factor |
| Category I | Category II | Category III |
|---|---|---|
| Extracellular | Growth factor and receptor | TGF-beta superfamily |
Reference Record 1
| PubMed ID | 25813565 | Compound ID | |
| CAS | Name | ||
| Model | human,mice | Fibrosis Disease | Renal fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Reference Record 2
| PubMed ID | 21527199 | Compound ID | |
| CAS | Name | ||
| Model | mice | Fibrosis Disease | Renal fibrosis |
| Process I | |||
| Process II | myofibroblasts differentiation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting Smad1/5/8 pathway | ||
Reference Record 3
| PubMed ID | 19741012 | Compound ID | |
| CAS | Name | ||
| Model | vitro | Fibrosis Disease | Renal fibrosis |
| Process I | |||
| Process II | cells proliferation,myofibroblasts differentiation | ||
| Process III | |||
| Mechanism | |||
Reference Record 4
| PubMed ID | 17562716 | Compound ID | |
| CAS | Name | ||
| Model | vitro,mice | Fibrosis Disease | Liver fibrosis |
| Process I | |||
| Process II | EMT | ||
| Process III | |||
| Mechanism | |||
Reference Record 5
| PubMed ID | 15047707 | Compound ID | |
| CAS | Name | ||
| Model | vitro | Fibrosis Disease | Renal fibrosis |
| Process I | |||
| Process II | |||
| Process III | |||
| Mechanism | |||
Reference Record 6
| PubMed ID | 30090401 | Compound ID | |
| CAS | Name | ||
| Model | vitro,rat | Fibrosis Disease | Pulmonary fibrosis |
| Process I | |||
| Process II | EMT | ||
| Process III | |||
| Mechanism | Targeting p38 MAPK/transcription factor signaling pathway | ||