Proheparin-binding EGF-like growth factor

Basic Information

Uniprot ID:	Q99075
Secondary ID:	B2R821
Symbol:	HBEGF
Other Name:	DTR,HB-EGF,HBEGF,Diphtheria toxin receptor,DT-R,Heparin-binding EGF-like growth factor,HB-EGF,HBEGF,Diphtheria toxin receptordivspan class="listify2 inner-title" title="Abbreviation of the full name or an acronym."Short name: span,DT-R
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Growth factor,Heparin-binding,Receptor

Target Classification

Category I	Category II	Category III
Extracellular	Growth factor and receptor	EGF family

Related Compound

Target ID	Name	Interaction
D1047	CRM197	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	28864379	Compound ID
CAS		Name
Model	mice	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs activation,HSCs proliferation,cells apoptosis
Process III	prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID	24303948	Compound ID	D1047
CAS		Name	CRM197
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation,cells apoptosis
Process III
Mechanism

Reference Record 3

PubMed ID	15856048	Compound ID
CAS		Name
Model	vitro,rabbit	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	fibroblasts activation
Process III	prevenet collagen deposition
Mechanism