Interleukin-1 receptor type 1

Basic Information

Uniprot ID: P14778
Secondary ID: Q587I7
Symbol: IL1R1
Other Name: IL1R,IL-1R-1,IL-1RT-1,IL-1RT1,CD121 antigen-like family member A,Interleukin-1 receptor alpha,IL-1R-alpha,Interleukin-1 receptor type I,p80,,mIL-1R1,mIL-1RI,sIL-1R1,sIL-1RI,Interleukin-1 receptor type 1, membrane form,Interleukin-1 receptor type 1, soluble form,mIL-1R1,mIL-1RI,sIL-1R1,sIL-1RI
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Receptor

Target Classification

Category I Category II Category III
Extracellular Cytokine and receptor Interleukin and receptor family

Related Compound

Target ID Name Interaction
D1029 Anakinra antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID 27004088 Compound ID D1029
CAS 143090-92-0 Name Anakinra
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation
Process III
Mechanism

Reference Record 2

PubMed ID 25607238 Compound ID D1029
CAS 143090-92-0 Name Anakinra
Model human,mice Fibrosis Disease Cystic fibrosis
Process I attenue inflammation
Process II
Process III
Mechanism Targeting IL-1R–MyD88 pathway

Reference Record 3

PubMed ID 20007584 Compound ID D1029
CAS 143090-92-0 Name Anakinra
Model mice Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting IL-1R1/MyD88 signaling

Reference Record 4

PubMed ID 17992263 Compound ID
CAS Name
Model mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism