Tumor necrosis factor ligand superfamily member 12

Basic Information

Uniprot ID: O43508
Secondary ID: Q8IZK7, Q8WUZ7
Symbol: TNFSF12
Other Name: APO3L,APO3 ligand,TNF-related weak inducer of apoptosis,TWEAK,Tumor necrosis factor ligand superfamily member 12, membrane form,Tumor necrosis factor ligand superfamily member 12, secreted form
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Cytokine,Developmental protein

Target Classification

Category I Category II Category III
Extracellular Cytokine and receptor TNF family

Related Compound

Fibrosis Related Property

Reference Record 1

PubMed ID 27888541 Compound ID
CAS Name
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II fibroblasts apoptosis
Process III
Mechanism Targeting SIRT1 and p53

Reference Record 2

PubMed ID 26924336 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferatio
Process III prevenet collagen deposition
Mechanism Targeting TWEAK/Fn14

Reference Record 3

PubMed ID 20724600 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Muscle fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting NF-κB

Reference Record 4

PubMed ID 20308426 Compound ID
CAS Name
Model mice Fibrosis Disease Muscle fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TWEAK–Fn14

Reference Record 5

PubMed ID 20164033 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III
Mechanism

Reference Record 6

PubMed ID 20098732 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Muscle fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 7

PubMed ID 19531747 Compound ID
CAS Name
Model human Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III
Mechanism

Reference Record 8

PubMed ID 19531747 Compound ID
CAS Name
Model human Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III
Mechanism