C-X-C chemokine receptor type 4

Basic Information

Uniprot ID: P61073
Secondary ID: B2R5N0
Symbol: CXCR4
Other Name: CXC-R4,CXCR-4,FB22,Fusin,HM89,LCR1,Leukocyte-derived seven transmembrane domain receptor,LESTR,Lipopolysaccharide-associated protein 3,LAP-3,LPS-associated protein 3,NPYRL,Stromal cell-derived factor 1 receptor,SDF-1 receptor,
Class: Single Protein
Type: pro-fibrotic
Molecular Function: G-protein coupled receptor,Host cell receptor for virus entry,Receptor,Transducer

Target Classification

Category I Category II Category III
Extracellular Cytokine and receptor Chemokine

Related Compound

Target ID Name Interaction
D0099 Plerixafor inhibitor
D0925 AM3-114 inhibitor
D0926 AM4-272 inhibitor
D0927 AM3-523 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 27960539 Compound ID D0099
CAS 110078-46-1 Name Plerixafor
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 25929952 Compound ID
CAS Name
Model human Fibrosis Disease Cystic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 3

PubMed ID 27036939 Compound ID D0925
CAS Name AM3-114
Model Fibrosis Disease Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 4

PubMed ID 27036939 Compound ID D0926
CAS Name AM4-272
Model Fibrosis Disease Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 5

PubMed ID 27036939 Compound ID D0927
CAS Name AM3-523
Model Fibrosis Disease Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 6

PubMed ID 22479424 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 7

PubMed ID 19434726 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,HSCs proliferation
Process III prevenet collagen deposition
Mechanism Targeting ERK 1/2 and PI3K-Akt pathways

Reference Record 8

PubMed ID 19433312 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III
Mechanism