Adenosine receptor A2a

Basic Information

Uniprot ID: P29274
Secondary ID: B2R7E0
Symbol: ADORA2A
Other Name: ADORA2
Class: Single Protein
Type: pro/anti-fibrotic
Molecular Function: G-protein coupled receptor,Receptor,Transducer

Target Classification

Category I Category II Category III
Extracellular G protein-coupled receptor Adenosine receptor

Related Compound

Target ID Name Interaction
D0034 CGS21680 agonist
D0352 8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]-triazine-3-carbohydrazide antagonist
D0353 SCH 58261 antagonist
D0576 ZM241385 antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID 28616713 Compound ID D0034
CAS 120225-54-9 Name CGS21680
Model vitro Fibrosis Disease Fibrosis
Process I
Process II EMT
Process III
Mechanism

Reference Record 2

PubMed ID 27658704 Compound ID
CAS Name
Model mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 23585831 Compound ID
CAS Name
Model mice Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 23412328 Compound ID
CAS Name
Model mice Fibrosis Disease Scar
Process I
Process II
Process III
Mechanism

Reference Record 5

PubMed ID 22792196 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 22063920 Compound ID D0352
CAS 1038994-42-1 Name 8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]-triazine-3-carbohydrazide
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation
Process III
Mechanism

Reference Record 7

PubMed ID 22063920 Compound ID D0353
CAS 160098-96-4 Name SCH 58261
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 8

PubMed ID 19221177 Compound ID D0576
CAS 139180-30-6 Name ZM241385
Model vitro,mice Fibrosis Disease Peritoneal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 18709547 Compound ID
CAS Name
Model mice Fibrosis Disease Scleroderma
Process I
Process II fibroblasts accumulation
Process III
Mechanism

Reference Record 10

PubMed ID 16871530 Compound ID D0576
CAS 139180-30-6 Name ZM241385
Model vitro,mice Fibrosis Disease Dermal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 16783407 Compound ID D0576
CAS 139180-30-6 Name ZM241385
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 12

PubMed ID 28979687 Compound ID
CAS Name
Model mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting SDF-1/CXCR4 axis-related pathway