| Uniprot ID: | P05305 |
| Secondary ID: | Q96DA1 |
| Symbol: | EDN1 |
| Other Name: | Preproendothelin-1,PPET1,ET-1,Endothelin-1,Big endothelin-1,ET-1 |
| Class: | Single Protein |
| Type: | pro-fibrotic |
| Molecular Function: | Vasoactive,Vasoconstrictor |
| Category I | Category II | Category III |
|---|---|---|
| Extracellular | G protein-coupled receptor | Endothelin receptor |
Reference Record 1
| PubMed ID | 25012164 | Compound ID | |
| CAS | Name | ||
| Model | vitro,mice | Fibrosis Disease | Peritoneal fibrosis |
| Process I | |||
| Process II | |||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting ET-1/TGF-β1 axis | ||
Reference Record 2
| PubMed ID | 24853267 | Compound ID | |
| CAS | Name | ||
| Model | mice | Fibrosis Disease | Skin fibrosis |
| Process I | |||
| Process II | |||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||
Reference Record 3
| PubMed ID | 22365964 | Compound ID | |
| CAS | Name | ||
| Model | mice | Fibrosis Disease | Cardiac fibrosis |
| Process I | |||
| Process II | |||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||
Reference Record 4
| PubMed ID | 21730058 | Compound ID | |
| CAS | Name | ||
| Model | vitro | Fibrosis Disease | Cardiac fibrosis |
| Process I | |||
| Process II | |||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||