Endothelin-1 receptor

Basic Information

Uniprot ID: P25101
Secondary ID: B2R723
Symbol: EDNRA
Other Name: ETA,Endothelin receptor type A,ET-A,ETA-R,hET-AR
Class: Single Protein
Type: pro-fibrotic
Molecular Function: G-protein coupled receptor,Receptor,Transducer

Target Classification

Category I Category II Category III
Extracellular G protein-coupled receptor Endothelin receptor

Related Compound

Target ID Name Interaction
D0204 Bosentan antagonist
D0238 Macitentan inhibitor
D0484 TA-0201 antagonist
D0963 BQ-123 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 26056233 Compound ID D0204
CAS 147536-97-8 Name Bosentan
Model vitro,human,mice Fibrosis Disease Scar
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 25438341 Compound ID D0238
CAS 441798-33-0 Name Macitentan
Model pig Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 25012164 Compound ID D0204
CAS 147536-97-8 Name Bosentan
Model vitro,mice Fibrosis Disease Peritoneal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ET-1/TGF-β1 axis

Reference Record 4

PubMed ID 25012164 Compound ID D0238
CAS 441798-33-0 Name Macitentan
Model vitro,mice Fibrosis Disease Peritoneal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ET-1/TGF-β1 axis

Reference Record 5

PubMed ID 24708674 Compound ID D0204
CAS 147536-97-8 Name Bosentan
Model vitro,mice Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting c-Abl - PKC-δ - Fli1

Reference Record 6

PubMed ID 21730058 Compound ID D0963
CAS 136553-81-6 Name BQ-123
Model vitro Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 21478482 Compound ID
CAS Name
Model pig Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 20730702 Compound ID D0238
CAS 441798-33-0 Name Macitentan
Model human Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 9

PubMed ID 12569276 Compound ID D0484
CAS 169679-53-2 Name TA-0201
Model vitro,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism