Endothelin B receptor

Basic Information

Uniprot ID:	P24530
Secondary ID:	A2A2Z8
Symbol:	EDNRB
Other Name:	ETRB,ET-B,ET-BR,Endothelin receptor non-selective type
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	G-protein coupled receptor,Receptor,Transducer

Target Classification

Category I	Category II	Category III
Extracellular	G protein-coupled receptor	Endothelin receptor

Related Compound

Target ID	Name	Interaction
D0204	Bosentan	antagonist
D0238	Macitentan	inhibitor
D0964	BQ-788	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	26056233	Compound ID	D0204
CAS	147536-97-8	Name	Bosentan
Model	vitro,human,mice	Fibrosis Disease	Scar
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID	25438341	Compound ID	D0238
CAS	441798-33-0	Name	Macitentan
Model	pig	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID	25012164	Compound ID	D0204
CAS	147536-97-8	Name	Bosentan
Model	vitro,mice	Fibrosis Disease	Peritoneal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting ET-1/TGF-β1 axis

Reference Record 4

PubMed ID	25012164	Compound ID	D0238
CAS	441798-33-0	Name	Macitentan
Model	vitro,mice	Fibrosis Disease	Peritoneal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting ET-1/TGF-β1 axis

Reference Record 5

PubMed ID	24708674	Compound ID	D0204
CAS	147536-97-8	Name	Bosentan
Model	vitro,mice	Fibrosis Disease	Systemic sclerosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting c-Abl - PKC-δ - Fli1

Reference Record 6

PubMed ID	21730058	Compound ID	D0964
CAS	156161-89-6	Name	BQ-788
Model	vitro	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID	20730702	Compound ID	D0238
CAS	441798-33-0	Name	Macitentan
Model	human	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I
Process II
Process III
Mechanism