Smoothened homolog

Basic Information

Uniprot ID: Q99835
Secondary ID: A4D1K5
Symbol: SMO
Other Name: SMOH,SMO,Protein Gx
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Developmental protein,G-protein coupled receptor,Receptor,Transducer

Target Classification

Category I Category II Category III
Extracellular G protein-coupled receptor Smoothened receptor

Related Compound

Target ID Name Interaction
D0068 Vismodegib antagonist
D0094 Cyclopamine inhibitor
D0340 LDE223 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28408356 Compound ID D0068
CAS 879085-55-9 Name Vismodegib
Model mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 28052321 Compound ID D0094
CAS 4449-51-8 Name Cyclopamine
Model vitro,mice,rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting hedgehog signaling

Reference Record 3

PubMed ID 26823780 Compound ID
CAS Name
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 24066108 Compound ID D0068
CAS 879085-55-9 Name Vismodegib
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II EMT,cells proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 22994359 Compound ID D0068
CAS 879085-55-9 Name Vismodegib
Model rat Fibrosis Disease Liver fibrosis
Process I
Process II EMT,HSCs activation,cells proliferation,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 22994359 Compound ID D0094
CAS 4449-51-8 Name Cyclopamine
Model rat Fibrosis Disease Liver fibrosis
Process I
Process II EMT,HSCs activation,cells proliferation,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 22402139 Compound ID D0340
CAS Name LDE223
Model mice Fibrosis Disease Dermal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting hedgehog signaling

Reference Record 8

PubMed ID 19577569 Compound ID D0094
CAS 4449-51-8 Name Cyclopamine
Model vitro,human,mice Fibrosis Disease Liver fibrosis
Process I
Process II EMT
Process III
Mechanism Targeting Hh signaling

Reference Record 9

PubMed ID 29065414 Compound ID D0094
CAS 4449-51-8 Name Cyclopamine
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism Targeting AKT/mTOR/p70S6K signaling