Proteinase-activated receptor 2

Basic Information

Uniprot ID: P55085
Secondary ID: Q13317, Q13346, Q53XJ8
Symbol: F2RL1
Other Name: GPR11,PAR-2,Coagulation factor II receptor-like 1,G-protein coupled receptor 11,Thrombin receptor-like 1,Proteinase-activated receptor 2, alternate cleaved 1,Proteinase-activated receptor 2, alternate cleaved 2
Class: Single Protein
Type: pro-fibrotic
Molecular Function: G-protein coupled receptor,Receptor,Transducer

Target Classification

Category I Category II Category III
Extracellular G protein-coupled receptor Other peptide receptor

Related Compound

Target ID Name Interaction
D0298 GB88 antagonist
D0987 PZ-235 antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID 27613872 Compound ID D0987
CAS Name PZ-235
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I regulate cytokines and growth factors,attenue inflammation
Process II HSC activation
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 27625162 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 3

PubMed ID 23964081 Compound ID D0298
CAS 1416435-96-5 Name GB88
Model vitro,rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 14565830 Compound ID
CAS Name
Model vitro,rat Fibrosis Disease Intestinal fibrosis
Process I
Process II
Process III
Mechanism